ID   MUTS_PEDPA              Reviewed;         873 AA.
AC   Q03EQ7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=PEPE_1274;
OS   Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 /
OS   183-1w).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Pediococcus.
OX   NCBI_TaxID=278197;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w;
RX   PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA   Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA   Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA   Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA   Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA   Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA   Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA   Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA   O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA   Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT   "Comparative genomics of the lactic acid bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000422; ABJ68315.1; -; Genomic_DNA.
DR   RefSeq; WP_011673584.1; NC_008525.1.
DR   AlphaFoldDB; Q03EQ7; -.
DR   SMR; Q03EQ7; -.
DR   STRING; 278197.PEPE_1274; -.
DR   EnsemblBacteria; ABJ68315; ABJ68315; PEPE_1274.
DR   GeneID; 33061705; -.
DR   KEGG; ppe:PEPE_1274; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000773; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..873
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008078"
FT   REGION          797..817
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         609..616
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   873 AA;  99173 MW;  5B64EEE5A05D400B CRC64;
     MPQKTSDTPM MRQYMEIKNQ YPDAFLFYRI GDFYELFYDD AVKGSQLLEL TLTARSKNAD
     DPIPMCGVPH HAAQNYIDIL VDQGYKVAIC EQMEDPRTAK GMVKREVIQL VTPGTTTDKS
     AEDAKENNYL TAVNFDSKTK KYGFAYTDLS TGELKVAILD DFDSVINEAV GLQTKEIVTD
     ESLAESFEER FKELNILVSK QSEVEISAEL SYLIQDLTSS TEIEVVKQLL TYVQTTQKRN
     LAHIQKAVAY EPSFFLRMDH ASKYNLELTR LIRTGKKQGT LLWLLDETKT AMGGRLLKQW
     LDRPLIRKKE IISRQDRVQV LVDHFFERSN LQEELTKVYD LERLAGRVAF GSVNGRDLIQ
     LKTSLLQIPK VRHILEELSE PVFDDALEHL DPVSDIAELI QNAIDEDAPI SVTDGDIIKD
     GYHAKLDEYR DAMRNGKKWI ADLQAQERAT TGIKTLKIGY NKVFGYYIEV TRANLANIPE
     GRYERKQTLT NAERFITPEL KEKERIILEA EQKSTDLEYQ LFKEIRELIK KQIERLQDLA
     KQVAELDVLQ SFAVVSEKYQ FVKPTMTKNH AIEIKDGRHP VVEKVMGHQS YVPNNIDMDD
     NTDILLITGP NMSGKSTYMR QLALTVIMAQ MGCFVAASEA TLPIFDQIFT RIGAADDLIS
     GQSTFMVEMQ EANRALKDGT SNSLVLFDEI GRGTATYDGM ALAQSIIEFI HQNVHAKTLF
     STHYHELTEL DQSLEHLKNV HVGAVEQNGN LVFLHKMEDG PADKSYGIHV AKLAGMPDKL
     LKRASVILEK LEAKDQAHSD GVETPVSKAT PVESEQTPTM IEEQMALFET PTKPVKSSPK
     EEVANQLEQL NLMDMTPMEV MNQLYKWQKK LRK