ID   MUTS_PELPD              Reviewed;         870 AA.
AC   A1AMW9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Ppro_1064;
OS   Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Desulfuromonadaceae; Pelobacter.
OX   NCBI_TaxID=338966;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 2379 / NBRC 103807 / OttBd1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Lovley D.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Pelobacter propionicus DSM 2379.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000482; ABK98689.1; -; Genomic_DNA.
DR   RefSeq; WP_011734993.1; NC_008609.1.
DR   AlphaFoldDB; A1AMW9; -.
DR   SMR; A1AMW9; -.
DR   STRING; 338966.Ppro_1064; -.
DR   EnsemblBacteria; ABK98689; ABK98689; Ppro_1064.
DR   KEGG; ppd:Ppro_1064; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_7; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000006732; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..870
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335192"
FT   REGION          813..834
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         621..628
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   870 AA;  96246 MW;  7059FA7A4A97656F CRC64;
     MADHTPMMRQ YLEIKSGYPD AVLFFRMGDF YEMFLDDALL ASRILDITLT SRNKGSGDEI
     PFCGVPYHSV TPYITKLIEN GHKVAICEQV EDPKQTKGIV RREVVRVITP GLLIETENLS
     PDDNNYLLAL HQGAEEQWGV AWLDLSTGEF RVTELAGPGS ALAEAVCINP AEVLLADGVR
     LEEFPADLKE YLAQKIVSRA PAWVYERDYT SSLICDQFGA ASPDVLGLEG LPSGLLAAGA
     ALYYLRENRK SAIPHIRDIR VYQRSEHLAL DPATRRNLEI TASMAEGKKS GSLLGCLDRT
     VTAMGARRLK QWLGYPLVGL EPIRSRLDAV EELLEGATTR DELAAQMKGI ADLERLNGRI
     GMASASGRDL RALHDSLQRI PPLRELMATM QTALLCQLTK EIDPLEDILD LVGRGIVENP
     PFSLREGGII APGYNPELDE LRSISHEGKG FIARLEAQER ARTGISSLKI RFNKVFGYSI
     EITKSNLASV PADYIRRQTL ANAERYITEE LKNYEEKVLG AEDRIHELEY SLFQEIRERV
     AGEGSRIACS ASGLATLDVL ISLAGVADER GYCKPLVDDS QVIDIHDGRH PVIEAMKLGE
     RFVPNDTLLD GGESQILMIT GPNMAGKSTY MRQVALITLM AQAGSFVPAA SARIGIADRI
     FTRVGAGDNL SRGQSTFMLE MMEAAGILRN ATPKSLIVMD EIGRGTSTFD GVSIAWAVAE
     YIHDTPTCRS RTLFATHYHE LTELAATRER IRNFTVAVRE WNDQVIFLRT IVPGGASHSY
     GIQVARLAGM PADVIERAKE ILRNLENGEF EEGAPRIAKS RRQRTPDPSP QFSLFESDED
     LLRTRLKKLN IATLTPLEAL NLLDELKRMA