ID   MUTS_PELTS              Reviewed;         863 AA.
AC   A5D2K2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=PTH_1339;
OS   Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Desulfotomaculaceae;
OC   Pelotomaculum.
OX   NCBI_TaxID=370438;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 13744 / JCM 10971 / SI;
RX   PubMed=18218977; DOI=10.1101/gr.7136508;
RA   Kosaka T., Kato S., Shimoyama T., Ishii S., Abe T., Watanabe K.;
RT   "The genome of Pelotomaculum thermopropionicum reveals niche-associated
RT   evolution in anaerobic microbiota.";
RL   Genome Res. 18:442-448(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AP009389; BAF59520.1; -; Genomic_DNA.
DR   AlphaFoldDB; A5D2K2; -.
DR   SMR; A5D2K2; -.
DR   STRING; 370438.PTH_1339; -.
DR   PRIDE; A5D2K2; -.
DR   EnsemblBacteria; BAF59520; BAF59520; PTH_1339.
DR   KEGG; pth:PTH_1339; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000006556; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..863
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335193"
FT   BINDING         615..622
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   863 AA;  96520 MW;  E2518A10E9855A2B CRC64;
     MIRQYLEIKK QYPDAILFFR LGDFYEMFFD DARLASRELE ITLTGRDGGS ERVPMCGIPY
     HAADGYIARL ISKGYRVAIC EQVEDPAEAK GIVRREVTRV ITPGTVTEGH FLEDKKNNYL
     ASIAPFEEGY GLAVTDITTG VFMVSSFSGV RAWSELIDEM ARLNPAEVII PLAYSDKMGG
     DLKQQGILAV SGYRDTAFSP AEAVPAFEEQ FGSAGSLCNR TIDYHAAVAA AGALLIFLRE
     TQKRVLKHIN KAAFYRPGKY MILDANTRRN LELTRAISDG SRRNTLLSVI DHTVTAMGGR
     LLRNWIEQPL LDVAEIKARL EATEDLAGNA MLRLELKSLL KNVYDLERLT GKISFGTANA
     RDLIGLKKSL ANLPLIKQLL LAQAGAALLK DVARSIDPLE EVRELLEAAI DDNPPLSLKD
     GGIIKKGYNH EVDRLRQARR EGKSMLAGLE ERERARTGIK SLKVGFNKVF GYYIEVTRAN
     LELVPEDYQR RQTLANAERF ITPELKEYED MILRAEERLA SLERRLFDEV LERLSGEIHR
     IQKSASAIAT ADALYSLAEA AVKGRYSRPE IAEDGKLHVK DGRHPVLEQV MGPGRFVPND
     TFMDNEESRF ILLTGPNMAG KSTYMRQVAL IVLLAQIGSF VPALFARIPV FDRIFTRVGA
     SDDIAGGQST FMVEMNECRI IVNEATEKSL IIMDEVGRGT STYDGISIAR ALAEYIHTKI
     RAKTLFSTHY HELTDLDSMP GIVNFNVAVR EEGEDIIFLR KVVPGKSDRS YGIQVARLAG
     LPGEIINRSM EILKTLELAA ERPPQPSPAK EWPAYRYKEN ECHVIQELRR LNVLEMTPLE
     AINKLYMLHK KLTESATLKT TSL