ID   MUTS_PERMH              Reviewed;         870 AA.
AC   C0QPF0;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=PERMA_0758;
OS   Persephonella marina (strain DSM 14350 / EX-H1).
OC   Bacteria; Aquificae; Aquificales; Hydrogenothermaceae; Persephonella.
OX   NCBI_TaxID=123214;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14350 / EX-H1;
RX   PubMed=19136599; DOI=10.1128/jb.01645-08;
RA   Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S.,
RA   Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A.,
RA   Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.;
RT   "Complete and draft genome sequences of six members of the Aquificales.";
RL   J. Bacteriol. 191:1992-1993(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001230; ACO04590.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0QPF0; -.
DR   SMR; C0QPF0; -.
DR   STRING; 123214.PERMA_0758; -.
DR   EnsemblBacteria; ACO04590; ACO04590; PERMA_0758.
DR   KEGG; pmx:PERMA_0758; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_0; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001366; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..870
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000118689"
FT   BINDING         608..615
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   870 AA;  100733 MW;  8DF5A9E6A72649FC CRC64;
     MKEEKNITPM LAQYHKIKDQ YPDALVLYRL GDFYEMFYED AHTGARELNI VLTKKKVGKD
     RYIPMCGIPF HSADSYITRL VSKGYKVAIC EQLEDASKAK GIVKRDVIRV LTPGTYFENE
     KLKSALLGIY QERGRFYIAY LDLSTGEFTG GSLNRDELIS FIGKFQPKEI VVQEGYDFSD
     LRSQFKSIFF SQLPEDYFSE DTHSEFLGFF KTGHISAFGF DTEEQNVIYP LSAVWKYAKV
     TQKSFLPFIS TPKPYREDSY VRLDYSAQKH LEIVSPNEGN IPLLRVMDRT LTGMGRRKLR
     FFLLHPLKNS KEIIKRQNAV TELVENTELR EKIRDILDQI FDIERLISKI SSNTSTPRDL
     VGLRESLKKV SKLKEISKEI KSDLLKESFE RIEDYSWLIE KLDRYLEDDP PIHLKEGGLI
     KKGVDKDLDE LKEIKEKGNE WLKSYQEKLR KETGIQSLKI GFNKVMGYYI EVTKPNLKLV
     PDHFRRRQTL SNAERFITDE LQSFEEKILS ADEKIKALEY EIFMRIREEV AFLSDRIGKT
     AQQVGMIDAI QSLAQIAVEK GWTKPDIHDG YEIEIKEGYH PVIKEFMPDF VPNNLKMNRN
     SYFHIITGPN MAGKSTFIRQ SAIIILLAQT GSYIPAKKGK IGVVDAIFTR IGSGDALAKG
     LSTFMVEMLE MANIVNNATE RSFIVLDEVG RGTSTYDGLS IGWAISEYLA EKVKVKTLFA
     THYHELTQLE REIKGVKNFH MDIFEDGENI KFLYRVKEGF SNKSYGVHVA KLAGIKEQII
     KRAYEILYYF EEQRDKKLEE DIYSLKQKEN SYLNEINELP LFKEIEDIEK DEYRQILEEI
     ESIDIGSITP VEALVFLNDL KKKIKRLKES