ID   MUTS_PETMO              Reviewed;         817 AA.
AC   A9BJY3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Pmob_1004;
OS   Petrotoga mobilis (strain DSM 10674 / SJ95).
OC   Bacteria; Thermotogae; Petrotogales; Petrotogaceae; Petrotoga.
OX   NCBI_TaxID=403833;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10674 / SJ95;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Detter J.C., Han C.,
RA   Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Noll K., Richardson P.;
RT   "Complete sequence of Petroga mobilis SJ95.";
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000879; ABX31726.1; -; Genomic_DNA.
DR   RefSeq; WP_012208829.1; NC_010003.1.
DR   AlphaFoldDB; A9BJY3; -.
DR   SMR; A9BJY3; -.
DR   STRING; 403833.Pmob_1004; -.
DR   EnsemblBacteria; ABX31726; ABX31726; Pmob_1004.
DR   KEGG; pmo:Pmob_1004; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_0; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000789; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..817
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335194"
FT   BINDING         604..611
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   817 AA;  94050 MW;  47DD34FF04B7BF5A CRC64;
     MSDLTPMIKQ YLKIKEEYKD SILLFRLGDF YETFFEDAKK VSEILQIVLT KRNGNPMAGI
     PYHALNNYLK RLLDAGYKVA ICEQMEDPQS SKGIVDRKVT RILTPGTIID EGMLEESNRF
     AALITKNGNL YKIAIFDFST GDFYLDSFDF KEDELLDFIS SFGLVQILLS KELEQLSKKI
     KNLTNEIYVE ILDEWYFSNN FKDHLKETYE VLSLDHLDYD DDELKVADAV LKYLEVTQFS
     KIKHMRLPKR FKTKNYMFLD SNTIENLGIL PTNSNKGKTL YDILKLTKTS MGNRKLREFI
     LTPLTDKENI EERLNKVEHL VEDPLLLEEL KEYLASVKDL ERISSRISLM KATPKDLIAL
     KDSLEVVPYI IESLTSNPGL SDFFDGVDVL KEAKEFIENT IIEEPAIAPG NGKVIKEGVS
     GELDEYRNLF NNLDGVLKDI EKREKEKTKI SSLKVGRNKI YGFYIEVSKA QSSKVPDNYV
     RKQTLVNTER YTIKELEEVE QRLALSEEKI KVIEKDIYDK VLTHLSQYVD KIEKLSNKIA
     ELDVFRSFAE VSRVYNYKRP TFVQNSKEIK IINSRHPVVE RFVDEFTPND LFLSEDKFYI
     ILTGPNMSGK STFIRQIGLI SVMAQIGCFV PAEKAEIPIY DGIFTRIGAR DDIVSGKSTF
     LVEMLEVSTI LNKATDNSLV LLDEVGRGTS TLDGISVAWA ISEYLFQVKR CNTIFATHYT
     ELTYMSHIYE EVAAKRIKVL ETMDGVIFLH KIEDGTSDNS YGIEIARLAG FPIEIIERSK
     EILSQLSNRV DLESRLKRIK NINKKKYESQ ENQLKMF