ID   MUTS_PHOLL              Reviewed;         851 AA.
AC   Q7N8K0;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=plu0722;
OS   Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS   TT01).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Photorhabdus.
OX   NCBI_TaxID=243265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15139 / CIP 105565 / TT01;
RX   PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA   Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA   Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX571861; CAE13017.1; -; Genomic_DNA.
DR   RefSeq; WP_011145097.1; NC_005126.1.
DR   AlphaFoldDB; Q7N8K0; -.
DR   SMR; Q7N8K0; -.
DR   STRING; 243265.plu0722; -.
DR   EnsemblBacteria; CAE13017; CAE13017; plu0722.
DR   GeneID; 24167922; -.
DR   KEGG; plu:plu0722; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   BioCyc; PLUM243265:PLU_RS03610-MON; -.
DR   Proteomes; UP000002514; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..851
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115116"
FT   BINDING         614..621
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   851 AA;  95210 MW;  371FB031C5FBEA6F CRC64;
     MINTETFDTH TPMMQQYLRL KAQHPDILLF YRMGDFYELF YDDAKKAAKL LDISLTKRGQ
     SAGNPIPMAG VPHHAVENYL AKLVQLGESV AICEQIGDPA TSKGPVERKV VRIVTPGTVT
     DEALLQERQD NLLAAIWHDN QGFGYATLDV TSGRFQISEM IELETIAAEL QRSRPVELLY
     PESFEHMALI ENFHGLRRRP LWEFELDTAK QQLNLQFGTR DLVGFGVDKA TLALRAAGCL
     LQYVKDTQRT ALPHIRGITM ERQQDTVIMD AATRRNLELT QNLSGSTDNT LASVLDLCVT
     PMGSRMLKRW LHAPVRDRQI LENRQQAIAT LQEIGLELQP FLLQIGDLER VLARLALRSA
     RPRDLARMRH AFQQLPDIHQ VMDSSDSPYI KQLQKNIGRF DELQELLEKA IVETPPVLIR
     DGGVIAPGYN SELDEWRTLA DGASNYLEQL EIREREKLGL DTLKVGFNGV HGYYIQVSRG
     QSHLVPIHYV RRQTLKNAER YIIPELKEYE DKVLTSKGKS LAIEKALYEE LFDLLLPHLA
     ELQTSAEALA ELDVLANLAE RAETLNYICP TLSDKPGIQI TGGRHPVVEQ VLREPFISNP
     LSLSSQRRLL IITGPNMGGK STYMRQAALI TLLAYIGSFV PAEKAVIGPV DRIFTRVGAS
     DDLASGRSTF MVEMTETANI LHNATEQSLV LMDEIGRGTS TYDGLSLAWA CAENLANRIK
     AMTLFATHYF ELTTLPEKLE GVVNIHLDAV EHGDTIAFMH SVQEGAASKS YGLAVASLAG
     VPREVIKRAR QKLKELESLS NHATASHVDT PQLALLTEET SPAVEALENL NPDSLTPRQA
     LEWIYRLKDM V