ID   MUTS_PHOPR              Reviewed;         856 AA.
AC   Q6LMU0;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=PBPRA3070;
OS   Photobacterium profundum (strain SS9).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Photobacterium.
OX   NCBI_TaxID=298386;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1253 / SS9;
RX   PubMed=15746425; DOI=10.1126/science.1103341;
RA   Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M.,
RA   Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C.,
RA   Bartlett D.H., Valle G.;
RT   "Life at depth: Photobacterium profundum genome sequence and expression
RT   analysis.";
RL   Science 307:1459-1461(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CR378673; CAG21386.1; -; Genomic_DNA.
DR   RefSeq; WP_011219646.1; NC_006370.1.
DR   AlphaFoldDB; Q6LMU0; -.
DR   SMR; Q6LMU0; -.
DR   STRING; 298386.PBPRA3070; -.
DR   EnsemblBacteria; CAG21386; CAG21386; PBPRA3070.
DR   KEGG; ppr:PBPRA3070; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000593; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..856
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224389"
FT   REGION          798..817
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        798..815
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         615..622
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   856 AA;  95193 MW;  F2B865E3664A4FD1 CRC64;
     MTVKGLETHT PMMQQFLRIK AENPDTLLFY RMGDFYELFF DDAKRASQLL DITLTKRGSS
     NGQPIPMAGL PYHAVEGYLA KLVQQGVSVA ICEQIGDPAT SKGPVDRQVV RIVTPGTVSD
     EALLSERRDN LVAAIYQNSK GFGYATLDIT SGRFMLSEPE TEEAMQAELQ RTSPAELLYP
     EDFTQMHIIE AIKGTRRRPV WEFDLDTARQ QLTMQFGTRD LIGFGVEKTE RGLSAAGCLL
     QYVKDTQRTA LPHIRAITLD SKDHSVILDA ATRRNLELTQ NLSGGFDNTL ASVLDHTATP
     MGSRLLKRWL HQPIRDTKQL NHRLDAIAAF KDTGMFIEVA EVLHHMGDLE RILARLALRS
     ARPRDLARMR SALQSLPQLA DLLADIEQPR IGELAKYSAP MDELCELLER AIIENPPVII
     RDGGVLAPGY NAELDEWRDL ADGAKKFLDD LETREREQHG IDSLKVGFNQ VHGFFIQISR
     GQSHLAPDHY VRRQTLKNAE RYIIPELKEH EDKVLSSKSK ALGLEKKLWE ELFDQLLPHL
     ERLQNAASAL SELDVLANLA ERADTLNYCR PELTDQTGIE IAAGRHPVVE QVLSEPFIAN
     PTSLHHDRRM LIITGPNMGG KSTYMRQTAL IALMAHVGSF VPAEAVKIGS LDRIFTRIGA
     SDDLASGRST FMVEMTETAN ILHNATSKSL VLMDEIGRGT STYDGLSLAW ASAEWLAEKI
     SAMTLFATHY FELTELPSMM DGLANVHLDA VEHGDEIAFM HAVQEGAASK SYGLAVASLA
     GVPKAVIKRA KAKLTQLETT GHQQAIKNPS KAPREEQQLT LLPEPSDVEE ALAKVNPDEM
     TPRQALDELY RLKALM