ID   MUTS_PHOV8              Reviewed;         870 AA.
AC   A6KZM1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BVU_1195;
OS   Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 /
OS   NBRC 14291 / NCTC 11154) (Bacteroides vulgatus).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Phocaeicola.
OX   NCBI_TaxID=435590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC
RC   11154;
RX   PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA   Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA   Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA   Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA   Knight R.D., Gordon J.I.;
RT   "Evolution of symbiotic bacteria in the distal human intestine.";
RL   PLoS Biol. 5:1574-1586(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000139; ABR38885.1; -; Genomic_DNA.
DR   RefSeq; WP_005849895.1; NC_009614.1.
DR   AlphaFoldDB; A6KZM1; -.
DR   SMR; A6KZM1; -.
DR   STRING; 435590.BVU_1195; -.
DR   EnsemblBacteria; ABR38885; ABR38885; BVU_1195.
DR   KEGG; bvu:BVU_1195; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_10; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   BioCyc; BVUL435590:G1G59-1242-MON; -.
DR   Proteomes; UP000002861; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..870
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335117"
FT   BINDING         617..624
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   870 AA;  97836 MW;  284423AE97CEF959 CRC64;
     MANDVVLTPM MKQFFELKAK HPDAIMLFRC GDFYETYSED AIVASEILGI TLTKRANGQA
     KSVEMAGFPF HALDTYLPKL VRAGKRVAIC DQLEDPKMTK KLVKRGITEL VTPGVAINDN
     VLSYKENNFL AAVHFGKASC GVAFLDISTG EFLTAEGPFD YIDKLLNNFA PKEVLFERGK
     RGMFEGNFGS KFFTFELDDW VFNESSSREK LLKHFETKNL KGFGVEHLKN GIVASGAILQ
     YLNMTQHYQI GHITSLSRIE EDRYVRLDKF TVRSLELIGS MNEGGTSLLD VIDRTISPMG
     ARLLKRWVVF PLKDEKPVNE RLDVVEYFFR EPDFKEFIEE KLHLIGDLER IVSKAAVGRI
     SPREVVQLKV ALQAIEPIKN ACLNADNGSL RRIGEQLNLC LSIREKIAKE VKNDPPLLVN
     KGGVIADGVN AELDELRQIA FSGKDYLLKV QQRESELTGI PSLKIAYNNV FGYYIEVRNT
     HKDKVPADWI RKQTLVNAER YITQELKEYE EKILGAEDKI LVLETKLYNE LVVALAEFIP
     AIQINASQIA RLDCLLAFAN VAKENNYIRP VVEDSEVIDI RQGRHPVIEK QLPVGEKYIA
     NDVFLDSETQ QIIIITGPNM AGKSALLRQT ALITLLAQMG SFVPAESARI GMVDKIFTRV
     GASDNISVGE STFMVEMNEA ANILNNLSSR SLVLFDELGR GTSTYDGISI AWAIVEHIHE
     HPKAKARTLF ATHYHELNEM EKSFKRIKNY NVSVKEIDNK VIFLRKLERG GSEHSFGIHV
     AKMAGMPKSI VKRANDILHQ LETDNRQQGI AKPTAEIASG RSGMQLSFFQ LDDPVLSQIR
     DEILNLDVNN LTPLEALNKL NDIKKIVKGK