ID   MUTS_POLNA              Reviewed;         870 AA.
AC   A1VLZ6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Pnap_1359;
OS   Polaromonas naphthalenivorans (strain CJ2).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Polaromonas.
OX   NCBI_TaxID=365044;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CJ2;
RX   PubMed=19453698; DOI=10.1111/j.1462-2920.2009.01947.x;
RA   Yagi J.M., Sims D., Brettin T., Bruce D., Madsen E.L.;
RT   "The genome of Polaromonas naphthalenivorans strain CJ2, isolated from coal
RT   tar-contaminated sediment, reveals physiological and metabolic versatility
RT   and evolution through extensive horizontal gene transfer.";
RL   Environ. Microbiol. 11:2253-2270(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000529; ABM36674.1; -; Genomic_DNA.
DR   RefSeq; WP_011800765.1; NC_008781.1.
DR   AlphaFoldDB; A1VLZ6; -.
DR   SMR; A1VLZ6; -.
DR   STRING; 365044.Pnap_1359; -.
DR   EnsemblBacteria; ABM36674; ABM36674; Pnap_1359.
DR   KEGG; pna:Pnap_1359; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000644; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..870
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335195"
FT   BINDING         629..636
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   870 AA;  94050 MW;  DD629F1855E22CAE CRC64;
     MQKDTLKPGE APVRAAPHTP MMTQYHAIKA EYPDTLVFYR MGDFYEVFYA DAEKASSLLD
     ITLTKRGQSA GEPVVMAGIP FHALEGYLAK LIKLGESVAI CEQVGDVATA KGPVERKVVR
     VVTPGTLTDT ELLSDKTESI LLAVHQGARN TCGLAWLSVT QGEIHLAHCA NGELETWLAR
     IAPSELLYNV DATPAFEQRL QTQRCAASAR PAWQFDAALG VRRLLDQLKV ASLASWHAEG
     LNEAHAAASA LLGYAEHTQG RALPHVQGLQ VVRSGELIEL PPATRRNLEL TQTLRGEDSP
     TLFSLLDTCT TGMGSRALKS WLLSPRRDRA QAASRLEAIT QLRSGAQQTL RTQLKGCSDV
     ERITARIALR QVRPRELVAL QLTLQKAELL TPVDSAQIPL LTTIFEDLQP PLGCAELLGQ
     CILDEPAALI RDGGVINHGL DAELDELRAI QTNCDGFLLD LEIREKARTG IANLRVQFNK
     VHGFYIEVTQ GQLDKVPADY RRRQTLKNAE RYITPELKTF EDKALSAQER ALAREKWLYE
     QLLDQLQEFV PALSRLARAI AALDALCALA ERSLTLNWCA PVFVKEPCIA IGQGRHPVVE
     ARLAETGGGA FIANDCSLTG KSRMQMITGP NMGGKSTYMR QVALIVLLAS VGSYVPASAC
     RLGPIDAIHT RIGAADDVAN AQSTFMLEML EAAQILHAAT PYSLVLMDEI GRGTSTFDGL
     ALAGGIAAYL HNKAQAFTLF ATHYFELTEF AAQHHGAMNV HVSAVESGSD IVFLHHIEPG
     PASKSYGIAV AKLAGVPAAV VNHARHALAA LEAQQSQASA QVDLFAAPPE APASGQTAID
     KALASIDPDI LSPREALEAL YQLKKLASAA