ID   MUTS_POLSJ              Reviewed;         864 AA.
AC   Q127P5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Bpro_3337;
OS   Polaromonas sp. (strain JS666 / ATCC BAA-500).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Polaromonas; unclassified Polaromonas.
OX   NCBI_TaxID=296591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JS666 / ATCC BAA-500;
RX   PubMed=18723656; DOI=10.1128/aem.00197-08;
RA   Mattes T.E., Alexander A.K., Richardson P.M., Munk A.C., Han C.S.,
RA   Stothard P., Coleman N.V.;
RT   "The genome of Polaromonas sp. strain JS666: insights into the evolution of
RT   a hydrocarbon- and xenobiotic-degrading bacterium, and features of
RT   relevance to biotechnology.";
RL   Appl. Environ. Microbiol. 74:6405-6416(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000316; ABE45247.1; -; Genomic_DNA.
DR   RefSeq; WP_011484242.1; NC_007948.1.
DR   AlphaFoldDB; Q127P5; -.
DR   SMR; Q127P5; -.
DR   STRING; 296591.Bpro_3337; -.
DR   PRIDE; Q127P5; -.
DR   EnsemblBacteria; ABE45247; ABE45247; Bpro_3337.
DR   KEGG; pol:Bpro_3337; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001983; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..864
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335196"
FT   BINDING         623..630
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   864 AA;  94258 MW;  C2EEA19F6741D290 CRC64;
     MTDPAKTHTP MMQQYLAIKA EYPDTLVFYR MGDFYEVFFA DAEKAARLLD ITLTRRGQSG
     GEPVVMAGVP FHSLEGYLAK LIKLGESVAI CEQVGDVATS KGPVERKVVR VVTPGTLTDT
     ELLNDKAESI LLAVHQGARN TCGLAWLSVT QGEIHLAHCA NDELETWLAR VNPSELLYNV
     DVTPAFEQRL KTQRCAASAR PAWQFDGALG ARRLLEQLKV ASLASWNAEA LNEAHAAASA
     LLGYAEHTQG RALPHVQGLQ VVRSGELIEL PQSTRRNLEL TQTLRGEDSP TLFSLLDTCS
     TGMGSRALKS WLLSPRRDRA QAQARLEAIA HLRSGPQQTL RARLKGCSDV ERITARLALR
     QVRPRELVAL RQTLDKLQQQ SERAAGESIG LPELLTRIFE DLQPPPGCTE LLGRYVLDEP
     AALIRDGGVI NHGCDADLDE LRAIQTNCDG FLLELEGRER ARTGIANLRV QFNKVHGFYI
     EVTQGQLDKV PDDYRRRQTL KNAERYITPE LKAFEDKALS AQERALAREK WLYEQLLDQL
     QAFIPALSRL ARALASLDAL CALAERSLTL NWAAPVFVKE PCIDITQGRH PVVEARLAET
     GGGSFIANDC SLSGKHRMQV ITGPNMGGKS TYMRQVALIV LLASVGSYVP AARCRLGPID
     AIHTRIGAAD DVANAQSTFM LEMTEAAQIL HTATPHSLVL MDEIGRGTST FDGLALAGGI
     AAYLHNKTQA FTLFATHYFE LTEFPAQHHG AINVHVSAVE SGANIVFLHH IEPGPASKSY
     GIAVAKLAGV PSAVVTHARH ALSALETQQT ETRAQVDLFA APPEAAAPVQ TALDRALDTI
     DPDTLSPREA LDALYQLKKL SALA