ID   MUTS_PORGI              Reviewed;         891 AA.
AC   Q7MXR7;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=PG_0095;
OS   Porphyromonas gingivalis (strain ATCC BAA-308 / W83).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Porphyromonadaceae;
OC   Porphyromonas.
OX   NCBI_TaxID=242619;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-308 / W83;
RX   PubMed=12949112; DOI=10.1128/jb.185.18.5591-5601.2003;
RA   Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E.,
RA   Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L.,
RA   Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J.,
RA   Granger D., Tettelin H., Dong H., Galvin J.L., Duncan M.J., Dewhirst F.E.,
RA   Fraser C.M.;
RT   "Complete genome sequence of the oral pathogenic bacterium Porphyromonas
RT   gingivalis strain W83.";
RL   J. Bacteriol. 185:5591-5601(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE015924; AAQ65342.1; -; Genomic_DNA.
DR   RefSeq; WP_005873956.1; NC_002950.2.
DR   AlphaFoldDB; Q7MXR7; -.
DR   SMR; Q7MXR7; -.
DR   STRING; 242619.PG_0095; -.
DR   EnsemblBacteria; AAQ65342; AAQ65342; PG_0095.
DR   KEGG; pgi:PG_0095; -.
DR   PATRIC; fig|242619.8.peg.88; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_10; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   BioCyc; PGIN242619:G1G02-88-MON; -.
DR   Proteomes; UP000000588; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..891
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115117"
FT   REGION          805..840
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         617..624
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   891 AA;  100680 MW;  283A5649A119E987 CRC64;
     MAKPVVETPL MRQYFQIKQK HPDAILLFRV GDFYETFSED AIVASEILGI TLTRRANGAA
     QFVELAGFPH HALDTYLPKL VRAGKRVAIC DQLEDPKKTK TLVKRGITEL VTPGVSTNDN
     VLSHKENNFL AAVSCGKEVF GISLLDISTG EFMAGQGNAD YVEKLLTNYR PKEILVERSE
     RSRFNDLFHW SGFIFDMEDW AFSSENNRLR VLKHFDLKSL KGFGLEELSM AVTAAGAVLN
     YLDLTQHHQL QHITSLSRLD ENRYVRLDKF TVRSLELLSP MNEGGKSLLD IIDHTITPMG
     ARRIRQWIVF PLKDPARIQA RQRVVEFFFR HPEERAIIAE HLTEIGDLER LVTKGAMGRI
     SPREMVQLRV ALQALEPIKE VCTHADEENL RTLGGKLELC KELRDKILRE VMPDAPAALG
     RGPVIAHGVD ATLDELRALA YSGKDYLIKL QQQEIERTGI PSLKVAYNNV FGYYIEVRNT
     HKDKVPAEWI RKQTLVSAER YITEELKEYE AKILGAEEKI AALEGQLYAL LVAELQRYVA
     PLQQDSQAVA SLDCLLSFAE SARRYRFICP VVDESFTIDI KAGRHPVIEQ QLPADEPYIA
     NDIYLDTDRQ QVIIVTGPNM SGKSALLRQT ALISLMAQIG SFVPAESARI GMVDSIFTRV
     GASDNISMGE STFMVEMQEA SNILNNLTPR SLVLFDELGR GTSTYDGISI AWSIVEYIHD
     NPKAHPRTLF ATHYHELNEL EGQLDRVHNF NVSAREVDGK MLFLRKLEPG GSAHSFGIQV
     ARLGGMPHHI VQRATDILHR LEQEREKIEE EEPKTKDTKR GPSEKVKNAS PTLPRDEKGR
     SIDGYQLSFF QLDDPVLSQI REEILDLNID NLTPLEALNK LNDIKRILRG Y