ID   MUTS_PROM0              Reviewed;         913 AA.
AC   A3PFD3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=P9301_18351;
OS   Prochlorococcus marinus (strain MIT 9301).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=167546;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 9301;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000576; ABO18458.1; -; Genomic_DNA.
DR   RefSeq; WP_011863742.1; NC_009091.1.
DR   AlphaFoldDB; A3PFD3; -.
DR   SMR; A3PFD3; -.
DR   STRING; 167546.P9301_18351; -.
DR   EnsemblBacteria; ABO18458; ABO18458; P9301_18351.
DR   KEGG; pmg:P9301_18351; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_3; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001430; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..913
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335198"
FT   REGION          18..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         720..727
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   913 AA;  103372 MW;  FFFD9EA5C59B6933 CRC64;
     MQEDLIIQKN LFAIGNDNNK QKEKTKIPED LSLEDLKKES QKRPRQRKNS TNLINKFKTD
     LISNKKNVCI NEESYSYKTV SKLKLTPVMK HYVTLKEENK DRLLLYRLGD FFECFFEDAV
     LISNLLEITL TSKDAGKEIG KIPMAGVPHH AMDRYCADLI KKNYSVVICD QLEKSSGNYG
     TPIKRGITRI ITPGTVIEEG MLIAKKNNWI TAIYLSEENS NESYEWGISK ADVSTGELIT
     LEGQSLSKLF DEIIKLDSSE IIVGSNAVRN LLIKGNSQIT YTVSQETNFG INEANYLIKN
     YFQIANLEGI GLKNLKNATR SLGGLLNYLE KINPSNLDKD SSVKISLDFP QIQYGHNKLI
     IDYQTQKNLE IKNTQRENNY VGSLLWSIDR TYTCMGARCL RRWIDSPLLN VNEIYKRQNI
     ITNFFESKKL RTDTQNLLRA MGDLERLAGR ACAGHASPRD LIAIAEGLKK LPRLKSIIEL
     FKYDLPNWTD QLINIDEGLL ELADTISFKL VENPPLSISE GGMIHDGVDN ILDGLRNLMD
     DYSEWLNKEE LKERKISKIS NLKIQFHKNF GYYISINKSK VNLAPQHWIK RQTLTNEERY
     ITSEIKNKEN KIFQIKSRAS SKEYEIFCEL RNIVAEKTKQ IRSIAKSIAS LDALLGLSIT
     SIENNFIKPL LIPINDSMTK NSTKIIAGRN PIVEQLLSDK KFVANDISFE DNQKLIILTG
     PNASGKSCFI RQLGLIQILA QIGSFVPANN AEIKIADRIF TRIGAVDDQS SGQSTFMVEM
     SETASILNQA TSNSLVLLDE IGRGTSTFDG LSIAWSVSEY LAKKIQCNTI FATHYHELNY
     LKNSNKNIQN FQVLVEQNDD QLIFSHRIVR GGSNKSYGIE AAKLAGVPKE VIEKAKSVLN
     SLEENNKLNH NIK