ID   MUTS_PROM1              Reviewed;         926 AA.
AC   A2C5A9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=NATL1_21131;
OS   Prochlorococcus marinus (strain NATL1A).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=167555;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NATL1A;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000553; ABM76669.1; -; Genomic_DNA.
DR   RefSeq; WP_011824613.1; NC_008819.1.
DR   AlphaFoldDB; A2C5A9; -.
DR   SMR; A2C5A9; -.
DR   STRING; 167555.NATL1_21131; -.
DR   EnsemblBacteria; ABM76669; ABM76669; NATL1_21131.
DR   KEGG; pme:NATL1_21131; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_3; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002592; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..926
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335201"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..46
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..67
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         726..733
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   926 AA;  103673 MW;  3D4B13CB691B7E9E CRC64;
     MAASPNPLQG SLFEESKQST TNGGKETNNS IGSSENLSNQ QLKSDASLRP RIRKTSKNPN
     QINDLDQLSN AEIEEPKWSH HNLPKIDDLT PALKHYVQLK IENPDRVLLY RLGDFFECFF
     EDAITLSQLL EITLTSKEGG KKIGKVPMAG IPHHASDRYC TELIKKGLSI AICDQLEAAP
     SKGNKLIKRG ITRLITPGTI IEEGMLSAKQ NNWLASVLLE SDSNSDFVNW SLAKLDVSTG
     EFLVQEGKET NNLRQELIKL KAAEVISESK SISNQNWYKG LIEITEFNQT SFSRLEAKTT
     IENHYFLNNI DGLGIHPESL SIRTIGGLIA YLNKTHPNIG NNLKNEVKTN ICIDFPQIKH
     NQAGLIIDNQ TRRNLEITST QKNGQFQGSL LWAIDKTLTA MGGRCIRRWL EEPLTEIYSI
     QSRQKIIGLL VESSSLRKNI RKILRAMGDL ERLSGRAGAQ QAGARDLIAI AEGINRLPLI
     KKYLNDPIFE ETKYFESIIN LDRDLIELAS KINNEIIDNP PLSLTEGGLI FDGVNPILDG
     LRNQLDDHNS WLKSQEIEER KNSNINNLKL QYHRSFGYFL AVSKAKSINV PDHWIRRQTL
     TNEERFVTPE LKEREGKIFQ LRARISQLEY DLFCKLRILV GNKSDIIRKA AKAISCLDVL
     SGLAELAATN NYIQPKIIDN KDSTKTRRLS IVDGRHPVVE QILVDKFFVP NDIELGSKTD
     LIILSGPNAS GKSCYLRQVG LLQIMAQIGS WIPAKSANIG IADQLFTRVG AVDDLASGQS
     TFMVEMIETA FILNNATENS LVLLDEIGRG TSTFDGLSIA WSVSEFLAKK IKSRSIFATH
     YHELNQISEY IENVENYKVV VEYKNHSLSF LHKVEKGGAN KSYGIEAARL AGVPPDVVNN
     ARLILKNLEK NNSNTIQITK PIESCK