ID   MUTS_PROM3              Reviewed;         927 AA.
AC   A2C5T5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=P9303_00881;
OS   Prochlorococcus marinus (strain MIT 9303).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=59922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 9303;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000554; ABM76845.1; -; Genomic_DNA.
DR   AlphaFoldDB; A2C5T5; -.
DR   SMR; A2C5T5; -.
DR   STRING; 59922.P9303_00881; -.
DR   EnsemblBacteria; ABM76845; ABM76845; P9303_00881.
DR   KEGG; pmf:P9303_00881; -.
DR   HOGENOM; CLU_002472_1_3_3; -.
DR   OMA; TPMMAQY; -.
DR   BioCyc; PMAR59922:G1G80-84-MON; -.
DR   Proteomes; UP000002274; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..927
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335199"
FT   REGION          44..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         725..732
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   927 AA;  102313 MW;  6417789333211AF9 CRC64;
     MTANAELLQG SLFGDLEPQA NAESCSETIT RALRNDLSDQ ELVDESLKRP RNRHKPTSVP
     SIPLDSESQE QLETADNDND LPAWAHHTLV DPEQLTPMLR HYVELKAKHP ERILLYRLGD
     FFECFFEDAI QLSRLLELTL TGKEGGKGIG RVPMAGVPHH AAERYCTELI RHGLSVAICD
     QLETTPSKGA LLKRDITRVL TPGTVLAEGM LTARRNNWLA AVVVEPAQGN QPFCWGLANA
     DVSTGEFLVT QREGSAELHQ HLAQLEASEL IMAQKIGESS RPAWCPEQLF LTTMATTPFS
     QPEAERTLLN HYRLSTLDGL GLQEVPLALR AAGGLLTYLR DTQPLAENVD EGIAPMPLEH
     PLTVFAGDAL VLDAQTRRNL ELTSTQRDGQ FQGSLLWAVD RTLTAMGARC LRRWIEAPLL
     DSKAIRARQA VVNHLVETRS LRHSLRRLLR PMGDLERLAG RAGAGHAGAR ELVAIADGIE
     RLPRLAEQLH NALRSAPNWL DNLLTLDKSL PKLAASIREQ LINNPPLSLS EGGLMHDNVD
     PLLDGLRNQL DDQDTWLAGQ EVQERKLSGN PNLRLQYHRT FGYFLAVSKA KASMVPDHWI
     RRQTLANEER FITPDLKTRE GQIFQLRARA CQREYELFCQ LREQVGKQAT SIRKAARAVA
     GLDALVGLAE VAATGDYCCP EIDNSRELQL KTCRHPVVEQ LLVERSFIPN DVELGKDIDL
     VVLTGPNASG KSCYLRQIGL IQLLAQVGSW VPAKQARVGI ADRIFTRVGA VDDLAAGQST
     FMVEMAETAN ILHHASDRSL VLLDEIGRGT ATFDGLSIAW AVSEHLARDL RSRTVFATHY
     HELNGLSQEL TNVANSQVLV EETGDDLVFL HQVAAGGANR SYGIEAARLA GVPDDVVQRA
     RQVLAQLHDD DSSLPALLSA KTIKRQS