ID   MUTS_PROM9              Reviewed;         913 AA.
AC   Q317Z7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=PMT9312_1737;
OS   Prochlorococcus marinus (strain MIT 9312).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=74546;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 9312;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Thiel J., Schmutz J., Larimer F.,
RA   Land M., Kyrpides N., Lykidis A., Richardson P.;
RT   "Complete sequence of Prochlorococcus marinus str. MIT 9312.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000111; ABB50798.1; -; Genomic_DNA.
DR   RefSeq; WP_011377279.1; NC_007577.1.
DR   AlphaFoldDB; Q317Z7; -.
DR   SMR; Q317Z7; -.
DR   STRING; 74546.PMT9312_1737; -.
DR   EnsemblBacteria; ABB50798; ABB50798; PMT9312_1737.
DR   KEGG; pmi:PMT9312_1737; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_3; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002715; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..913
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335200"
FT   BINDING         720..727
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   913 AA;  103902 MW;  FC16BB9619932F98 CRC64;
     MKEDTIIQKN LFAIDNENNE QKEITKIPED LSWEDLKKES QKRPRQRKNT TNLINKFKTD
     LISKNKNVCI NEESYSYKTV SKLKLTPVMK HYVTLKEENK DRLLLYRLGD FFECFFEDAV
     LISNLLEITL TSKDAGKEIG KIPMAGVPYH AMERYCADLI KKNYSVVICD QLEKSSGNYG
     TPIKRGITRI ITPGTVIEEG MLIAKKNNWI TAIYLSEENS NESYEWGISK ADVSTGELIT
     MEGQSLSKLF DEIIKLDSSE IIIGSNEVRN LLMNGNSQIS YTVSQETNFG INEANYLIKK
     YFQIVSLEGI GLKNLNNATR SLGGLLNYLK KINPLNLDKD SSVKISLDFP QIQFCHNKLI
     IDYQTQKNLE IKNTQRENNY VGSLLWSIDR TYTCMGARCL RRWIDSPLLN VNEIYKRQNI
     ISNFIESKQV RMDTQNLLRA MGDLERLAGR ACAGHASPRD LIAIAEGLKK LPRIKSIIEL
     FKYDLPDWTD QLKNIDEELL ELADTISFQL IEHPPLNISE GGMIHDGVDN ILDGLRNLMD
     DYSEWLNQEE LKERKISKIS NLKIQFHKNF GYYISINKSK VNLAPQHWIK RQTLTNEERY
     ITTDIKNKEN KIFQIKSRAS SREYEIFCEL RKMVAEKTKQ IRSIAKSIAS LDALLGLSIT
     SVENNFIKPA LIPINDSQKK NSTKIIAGRN PIVEQLLNDK KFTANDICFD DNQKLIILTG
     PNASGKSCFI RQIGLIQILA QIGSFIPANK AEIKIADRIF TRIGAVDDQS SGQSTFMVEM
     SETASILNQA TSSSLVLLDE IGRGTSTFDG LSIAWSVSEY LAKKIKCNTI FATHYHELNY
     LKNSNKNIEN FQVLVEQNND QIIFSHKIKK GGSNKSYGIE AAKLAGVPRE VIEKAKLVLN
     SLEENNKFNK NND