ID   MUTS_PROMA              Reviewed;         914 AA.
AC   Q7V9M5;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Pro_1805;
OS   Prochlorococcus marinus (strain SARG / CCMP1375 / SS120).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=167539;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SARG / CCMP1375 / SS120;
RX   PubMed=12917486; DOI=10.1073/pnas.1733211100;
RA   Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M.,
RA   Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S.,
RA   Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J.,
RA   Tandeau de Marsac N., Weissenbach J., Wincker P., Wolf Y.I., Hess W.R.;
RT   "Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a
RT   nearly minimal oxyphototrophic genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE017126; AAQ00849.1; -; Genomic_DNA.
DR   RefSeq; NP_876196.1; NC_005042.1.
DR   RefSeq; WP_011125954.1; NC_005042.1.
DR   AlphaFoldDB; Q7V9M5; -.
DR   SMR; Q7V9M5; -.
DR   STRING; 167539.Pro_1805; -.
DR   PRIDE; Q7V9M5; -.
DR   EnsemblBacteria; AAQ00849; AAQ00849; Pro_1805.
DR   GeneID; 54201135; -.
DR   KEGG; pma:Pro_1805; -.
DR   PATRIC; fig|167539.5.peg.1907; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_3; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001420; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..914
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115118"
FT   REGION          28..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..54
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         726..733
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   914 AA;  101957 MW;  A59B8E61CD0DEA7E CRC64;
     MTAENTPLQG NLFVESEENL LDANSLQNTN SVKDSNLNDE ELSKNAELRP RKRKKSVLLQ
     NSVGEQTEDF SNDERPAWSH HSLVEINELT PVLRHYVELK QKHPERILLY RLGDFFECFF
     EDAIGLSELL ELTLTGKEGG KKIGRVPMAG IPHHAAERYC STLIQKGLSV AICDQLESIQ
     NKEGKLLKRG ITRILTPGTV LEEGMLQAKK NNWLAAILIE SNSQTNQLKW GLASADISTG
     EFTVKEGNGI DTLEQDLLNI EASEIICEQL DVDISKKWQS NRIKITQQSK TSFSLQEAKA
     ILKKHYNLKT INGLGLNETE LALRAAGGLL YYLKETNPIH NIGVKNKCSK VVLDFPKNNL
     RGDSLIIDAQ TRRNLELTKT QKDGHFQGSL LCAIDRTLTA MGGRCLRRWI ENPLINSELI
     LQRQRLITLL VEKRPLRKAL RNLLRTMGDI ERLSGRASAG QAGARELVAI ADCLEKLPKL
     AANLQNLSIN PPKWFSKLEN INPELTKLAE EIKDKLIDNP PLSITEGNLI NDSVDKILDG
     LRNQLDDQNE WLSNQEKKER NISGNNNLKL QHHRTFGYFL AVSKSKANTV PDHWIRRQTL
     ANEERFVTPA LKERESKIFQ LKVKAANREY DLFCALRELV GGYAPIIRET AKAIAGLDVL
     LGLAELASTN NYCAPNIIDK KSLSNSRSIN IKGCRHPVVE QMLVEEKFQA NDIELGDGVD
     LIILTGPNAS GKSCYLRQIG LIQILSQIGS WIPADKASIS IADRVFTRVG AVDDLAAGQS
     TFMVEMAETA FILNQATQDS IVLLDEIGRG TSTFDGLSIA WSVSEFLAEN IKSRTIFATH
     YHELNELAKK MGNVANFQVL VHETGEDIHF LHQVIPGGSN RSYGIEAARL AGVPKSVINR
     ARGVLKRLEE KNKG