ID   MUTS_PROMH              Reviewed;         854 AA.
AC   B4F220;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=PMI2235;
OS   Proteus mirabilis (strain HI4320).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Proteus.
OX   NCBI_TaxID=529507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HI4320;
RX   PubMed=18375554; DOI=10.1128/jb.01981-07;
RA   Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S.,
RA   Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T.,
RA   Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H.,
RA   Rabbinowitsch E., Walker D., Whithead S., Thomson N.R., Rather P.N.,
RA   Parkhill J., Mobley H.L.T.;
RT   "Complete genome sequence of uropathogenic Proteus mirabilis, a master of
RT   both adherence and motility.";
RL   J. Bacteriol. 190:4027-4037(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AM942759; CAR44439.1; -; Genomic_DNA.
DR   RefSeq; WP_012368294.1; NC_010554.1.
DR   AlphaFoldDB; B4F220; -.
DR   SMR; B4F220; -.
DR   STRING; 529507.PMI2235; -.
DR   EnsemblBacteria; CAR44439; CAR44439; PMI2235.
DR   GeneID; 6802723; -.
DR   KEGG; pmr:PMI2235; -.
DR   PATRIC; fig|529507.6.peg.2182; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000008319; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..854
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093637"
FT   BINDING         615..622
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   854 AA;  95738 MW;  97480B0F0C54C35C CRC64;
     MTDSQNFESH TPMMQQYLKL KAEHPEILLF YRMGDFYELF FDDAKKASRL LDISLTKRGQ
     SAGQPIPMAG VPHHAVENYL AKLVQLGESV AICEQIGDPA TSKGPVERKV IRIVTPGTVT
     DEALLEERQD NLLAAIWQDK NGAFGYATLD ITSGRFRVTE MPDSESMAAE LQRTHPAELL
     YPETFESMAL IERQQGLRRR PIWEFECETA KQQLNLQFGT RDLTGFGVEN ARLALCAAGC
     LLQYVKDTQR TGLPHIRSIT MERPQDTIIL DAATRRNLEL TQNLAGGCDN TLASVLDLCV
     TPMGSRMLKR WIHTPLRQRE QLIKRQDAIS ALQPLYFELQ PFLRQVGDLE RVLARLALRS
     ARPRDLSRMR HAFQQYQDIH QVLDQADMPY IKELQQRISQ FDELRELLEN AIVETPPVLV
     RDGGVIASGY NAELDEWRAL ADGASDYLEK LEVREREKWG IDTLKVGFNG VHGYYIQVSR
     GQSNLVPMHY VRRQTLKNAE RYIIPELKEY EDKVLTSKGK ALAIEKMLYE ELFEKLLPHL
     TALQTSAEAL AETDVLANLA ERAESLNYTR PELTEKTGIQ ITGGRHPVVE QVLSEPFISN
     PLQLAPQRRL LIITGPNMGG KSTYMRQAAL ITLLAYIGSF VPAEKAVIGP IDRIFTRVGA
     SDDLASGRST FMVEMTETAN ILHNATENSL VLMDEIGRGT STYDGLSLAW ACAENLANRI
     KAMTLFATHY FELTTLPEKL EGTANIHLDA VEHGETIAFM HSVQEGAASK SYGLAVAALA
     GVPKEVIRRA KQKLKELETL SGHSGASHVE TSQLMLLADI EPSEVELALN KIDPDSLTPK
     QALELLYHLK ELNK