ID   MUTS_PROMM              Reviewed;         927 AA.
AC   Q7V978;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=PMT_0079;
OS   Prochlorococcus marinus (strain MIT 9313).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=74547;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 9313;
RX   PubMed=12917642; DOI=10.1038/nature01947;
RA   Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A.,
RA   Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L.,
RA   Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C.,
RA   Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R.,
RA   Chisholm S.W.;
RT   "Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche
RT   differentiation.";
RL   Nature 424:1042-1047(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; BX548175; CAE20254.1; -; Genomic_DNA.
DR   RefSeq; WP_011129458.1; NC_005071.1.
DR   AlphaFoldDB; Q7V978; -.
DR   SMR; Q7V978; -.
DR   STRING; 74547.PMT_0079; -.
DR   EnsemblBacteria; CAE20254; CAE20254; PMT_0079.
DR   KEGG; pmt:PMT_0079; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_3; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001423; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..927
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115119"
FT   REGION          44..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..70
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         725..732
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   927 AA;  102151 MW;  4DAF1D263D0C8024 CRC64;
     MTANAELLQG SLFGDLEPQA NAESCSETIA RALRNDLSDQ ELVDESLKRP RNRHNPTSVP
     SIPLDSESQE QLETADNDND LPAWAHHNLV DPEQLTPMLR HYVELKAKHP ERILLYRLGD
     FFECFFEDAI QLSRLLELTL TGKEGGKGIG RVPMAGVPHH AAERYCAELI RHGLSVAICD
     QLETTASKGA LLKRDITRVL TPGTVLAEGM LTARRNNWLA AVVVEPAQGN QPFCWGLANA
     DVSTGEFLIT QREGSAELHQ HLAQLEASEL IMAQKIGESS RPEWCPEQLF LTTMATTPFS
     QPEAERTLLN HYRLSTLDGL GLQEVPLALR AAGGLLTYLR DTQPLAENVD EGIAPMPLEH
     PLTVFAGDAL VLDAQTRRNL ELTSTQRDGQ FQGSLLWAVD RTLTAMGARC LRRWIEAPLL
     DSKAIRARQA VVNHLVETRS LRHSLRRFLR PMGDLERLAG RAGAGHAGAR ELVAIADGIE
     RLPRLAEQLH NALSSAPHWL DNLLTLDKSL PKLAASIREQ LINNPPLSLS EGGLMHDNVD
     PLLDGLRNQL DDQDTWLAGQ EIQERKLSGN PNLRLQYHRT FGYFLAVSKA KASMVPDHWI
     RRQTLANEER FITPDLKTRE GQIFQLRARA CQREYELFCQ LREQVGKQAT SIRKAARAVA
     GLDALVGLAE VAATGDYCCP EIDDSRELQL KTCRHPVVEQ LLVERSFIAN DVELGKDIDL
     VVLTGPNASG KSCYLRQIGL IQLLAQVGSW VPAKQARVGI ADRIFTRVGA VDDLAAGQST
     FMVEMAETAN ILHHASDRSL VLLDEIGRGT ATFDGLSIAW AVSEHLATDL RSRTVFATHY
     HELNGLSQEL TNVANFQVLV EETGDDLVFL HQVAAGGANR SYGIEAARLA GVPNDVVQRA
     RQVLAQLQDD GSSLPALPSA KTINRPS