ID   MUTS_PROMP              Reviewed;         915 AA.
AC   Q7UZL6;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=DNA mismatch repair protein MutS;
GN   Name=mutS; OrderedLocusNames=PMM1645;
OS   Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / NIES-2087 /
OS   MED4).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=59919;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCMP1986 / NIES-2087 / MED4;
RX   PubMed=12917642; DOI=10.1038/nature01947;
RA   Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A.,
RA   Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L.,
RA   Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C.,
RA   Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R.,
RA   Chisholm S.W.;
RT   "Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche
RT   differentiation.";
RL   Nature 424:1042-1047(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; BX548174; CAE20104.1; -; Genomic_DNA.
DR   RefSeq; WP_011133272.1; NC_005072.1.
DR   AlphaFoldDB; Q7UZL6; -.
DR   SMR; Q7UZL6; -.
DR   STRING; 59919.PMM1645; -.
DR   EnsemblBacteria; CAE20104; CAE20104; PMM1645.
DR   KEGG; pmm:PMM1645; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_3; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001026; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..915
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115120"
FT   REGION          18..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         720..727
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   915 AA;  103843 MW;  259F6A6B789808BC CRC64;
     MEEDTIIQKD LFAINHELKR PNNSSQIPDD LSTEELKKES QKRPRQRKNS TNLINKFKNN
     SNSERKNDCI NEKSYSYKTV EKQKLTPILK HYVTLKEENS NRLLLYRLGD FFECFFEDAV
     FISNLLEITL TSKDAGKDIG KIPMAGVPYH AMERYCAELI KKNHSVVICD QLEKSTGNYG
     TPLKRGITRI ITPGTVIEEG MLVAKKNNWI TAIHLSENIS ENLYEWGISR ADVSTGELLT
     MEGQSISKLF DEIIKLDTSE IIIGSNEEKK LLENQNQQIT YTVTQETFFS INEACLTIKN
     YFQILSLEGL GLKHLNNATK ALGGLLNYLE KINPSNLEND SSLKISLDFP QIQFPKDHLI
     IDYQTQKNLE IKNTQRENNY AGSLLWSIDR TYTCMGARCL RRWIDSPLLN IDEINKRQNI
     ISNFLESKKL RTDTQNILRA MGDLERLSGR ACAGHASPRD LIAISEGLKK LPRLKSIVKL
     FKYEIPSWTN QLKNIDNELL ELADLISFKL VQNPPLNTSE GGIIHDGVDN VLDGLRNLID
     DYSDWLNQEE LKERKISKIS NLKIQFHKNF GYYISINKSK VNLAPAHWIK RQTLTNEERY
     VTTEIKNRES KIFQVKNRAA AKEYELFCEV RNLVSAKTKR IRSVAKAIAC IDALLGLAIT
     SLENNFIKPT ISPITNSTDQ QSTKIIGGRN PIVEQLLTNR KFISNDILFN NKQKLIILTG
     PNASGKSCFI RQIGLIQILA QIGSFVPASK ADIQIVDRIF TRIGAVDDQS TGQSTFMVEM
     SETASILNQA TSNSLVLLDE IGRGTSTFDG LSIAWSVSEY LAKKIVCNTI FATHYHELNY
     LKHTNTNVEN FQVLVKQKKD QLFFCHKIEK GGANKSYGIE AAKLAGVPKE VINKAILVLD
     YLEKNNQLNA QIKIK