ID   MUTS_PROMS              Reviewed;         913 AA.
AC   A2BTM6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=A9601_18541;
OS   Prochlorococcus marinus (strain AS9601).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=146891;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AS9601;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000551; ABM71137.1; -; Genomic_DNA.
DR   RefSeq; WP_011819255.1; NC_008816.1.
DR   AlphaFoldDB; A2BTM6; -.
DR   SMR; A2BTM6; -.
DR   STRING; 146891.A9601_18541; -.
DR   EnsemblBacteria; ABM71137; ABM71137; A9601_18541.
DR   KEGG; pmb:A9601_18541; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_3; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002590; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..913
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335197"
FT   BINDING         720..727
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   913 AA;  103303 MW;  BC01F362EFC18EFD CRC64;
     MQEDTIIQKN LFAIGNDINE QKKITKIPEN LSLEDLKKES QKRPRQRKNS TNLINKFKTD
     LISNNKNVCI NEESYSYKTV SKLKLTPVMK HYVTLKEENK DRLLLYRLGD FFECFFEDAV
     LISNLLEITL TSKDAGKEIG KIPMAGVPHH AMERYCADLI KKNYSVVICD QLEKSSGNYG
     TPIKRGITRI ITPGTVIEEG MLIAKKNNWI SAIYLSEENS DESYEWGISK ADVSTGELIT
     LEGQSLSKLF DEIIKLDSSE IIVGSNTARD LLIKGNSQIT YTVSQETNFG INEANYLIKN
     YFQIANLEGI GLKNLNNATR SLGGLLNYLE KINPSNLDKD SSLKISLDFP QIQYGHNKLI
     IDYQTQKNLE IKNTQRENNY VGSLLWSIDR TYTCMGARCL RRWIDSPLLN VNEIYKRQNI
     ITNFLESKKL RIDTQNLLRA MGDLERLAGR ACAGHASPRD LIAIAEGLKK LPRLKSIIEL
     FKYDLPDWTD QLKNIDEGLL ELADTISFKL VENPPLNISE GGMIHDGVDN ILDGLRNLMD
     DYSEWLNKEE SKERKISKIS NLKIQFHKNF GYYISINKSK VNLAPQHWIK RQTLTNEERY
     ITSEIKNKEN KIFQIKSRAS SKEYEIFCEL RNIVAEKTKQ IRSIAKSIAS LDALLGLSIT
     SVENNFIKPS LIPINDSMTK NSTKIIAGRN PIVEQLLSDK KFVANDISFE DNQKLIILTG
     PNASGKSCFI RQLGLIQILT QIGSFVPANN AEIKIADRIF TRIGAVDDQS SGQSTFMVEM
     SETASILNQA TSSSLVLLDE IGRGTSTFDG LSIAWSVSEY LAKKIQCNTI FATHYHELNY
     LKNTNKNIQN FQVLVEQNND QLIFSHRIVK GGSNKSYGIE AAKLAGVPKE VIEKAKSVLN
     SLEENNKLNY DIK