ID   MUTS_PROMT              Reviewed;         926 AA.
AC   Q46IE5;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=PMN2A_1243;
OS   Prochlorococcus marinus (strain NATL2A).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=59920;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NATL2A;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000095; AAZ58733.1; -; Genomic_DNA.
DR   RefSeq; WP_011295587.1; NC_007335.2.
DR   AlphaFoldDB; Q46IE5; -.
DR   SMR; Q46IE5; -.
DR   STRING; 59920.PMN2A_1243; -.
DR   EnsemblBacteria; AAZ58733; AAZ58733; PMN2A_1243.
DR   KEGG; pmn:PMN2A_1243; -.
DR   HOGENOM; CLU_002472_1_3_3; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   PhylomeDB; Q46IE5; -.
DR   Proteomes; UP000002535; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..926
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224390"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         726..733
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   926 AA;  103958 MW;  81CC2F7A30619CC8 CRC64;
     MAASQNPIQG SLFGGNEESD LNKAEKLKGS ERSNVNLSHQ QLKEDASLRP RIKQTPKNPN
     QIIDLDELSR LAIEEPKWSH HNLPKIDDLT PALRHYVELK KENPDRVLLY RLGDFFECFF
     EDAITLSKLL EITLTSKEAG KKIGKIPMAG IPHHASDRYC TELIKKGLSI AICDQLEAAP
     TKGNKLIKRG ITRLITPGTI LEEGMLSAKK NNWLASVLLE AKSNQEIIDW SLAKIDVSTG
     EFIVQEGQGS NNLRHELIKL NAAEVISEKK SISNKIWYEG LIEITEFNRT SFSNLEAITT
     IKNHYCLNNI DSLGIHSNSL SIRTIGGLIS YLNKTHPNID DKSNNEIKTN ICIDYPRIKN
     SRSGLIIDSQ TRRNLEITST QKDGKFQGSL LWAIDKTLTA MGARCIRRWI EEPTKDVNAI
     KNRQNIIGFL VKSSTLRKNI RKTLRAMGDL ERLSGRAGAQ QAGARDLVAI AEGINRLPLI
     KNYLNEPIFD KTKYFDSIIN IDKDLIELAS KINNQIIDNP PLSLTEGGLF YDGINPVLDG
     LRNQLDDHNI WLNSQELEER KKSNINNLKL QYHRSFGYFL AVSKSKAINV PDHWIRRQTL
     TNEERFVTPG LKEREGKIFQ VRARISELEY ELFCDLRKLT GSKSNIIRQA AKAISHLDVL
     TGLAELAANH NYIQPQIIDM NEQDKSRKLS IIDGRHPVVE QILVDKVFVP NDIELGSKTD
     LIILSGPNAS GKSCYLRQVG LLQIMAQIGS WIPAKSAHMG IADQVFTRVG AVDDLASGQS
     TFMVEMIETA FILNNATENS LVLLDEIGRG TSTFDGLSIA WSVSEFLAKK IKSRSIFATH
     YHELNQISEY IENVENYKVV VEYKNHSLSF LHKVERGGAN KSYGIEAARL AGVPPDVVNN
     ARLILKNLEK NNSNTIQITK PIESCK