ID   MUTS_PSE14              Reviewed;         859 AA.
AC   Q48F92;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=PSPPH_3807;
OS   Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6)
OS   (Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=264730;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1448A / Race 6;
RX   PubMed=16159782; DOI=10.1128/jb.187.18.6488-6498.2005;
RA   Joardar V., Lindeberg M., Jackson R.W., Selengut J., Dodson R.,
RA   Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Gwinn Giglio M.,
RA   Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A., Crabtree J.,
RA   Creasy T., Davidsen T.M., Haft D.H., Zafar N., Zhou L., Halpin R.,
RA   Holley T., Khouri H.M., Feldblyum T.V., White O., Fraser C.M.,
RA   Chatterjee A.K., Cartinhour S., Schneider D., Mansfield J.W., Collmer A.,
RA   Buell R.;
RT   "Whole-genome sequence analysis of Pseudomonas syringae pv. phaseolicola
RT   1448A reveals divergence among pathovars in genes involved in virulence and
RT   transposition.";
RL   J. Bacteriol. 187:6488-6498(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000058; AAZ37785.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q48F92; -.
DR   SMR; Q48F92; -.
DR   STRING; 264730.PSPPH_3807; -.
DR   PRIDE; Q48F92; -.
DR   EnsemblBacteria; AAZ37785; AAZ37785; PSPPH_3807.
DR   KEGG; psp:PSPPH_3807; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000551; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..859
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224394"
FT   REGION          799..821
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         617..624
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   859 AA;  95476 MW;  B590385C88C5E15D CRC64;
     MNKAISDLSS HTPMMQQYWK LKNQHLDQLM FYRMGDFYEI FYEDAKKAAK LLDITLTARG
     QSAGQSIPMC GIPYHAAEGY LAKLVKLGES VVICEQIGDP ATSKGPVDRQ VVRIITPGTI
     SDEALLDERR DNLIAAVLGD ERLFGLAVLD ITSGNFSVLE IKGWENLLAE LERINPVELL
     IPDDWPQGLP AEKRRGARRR APWDFERDSA HKSLCQQFST QDLKGFGCEN LTLAIGAAGC
     LLSYAKETQR TALPHLRSLR HERLDDTVIL DAASRRNLEL DTNLSGGRDN TLQSVMDRCQ
     TAMGTRLLTR WLNRPLRDLT ILQARQTSIT CFLERYRFEN LQPQLKEIGD IERILARIGL
     RNARPRDLAR LRDALSALPE LQQAMTDLEA PHLQQLAQTA STYPELADLL QRAIIDNPPA
     VIRDGGVLKT GYDAELDDLQ SLSENAGQFL IDLEAREKAR TGLANLKVGY NRVHGYFIEL
     PSKQAEQAPA DYIRRQTLKG AERFITPELK EFEDKALSAK SRALAREKML YEALLEDLIG
     HLAPLQDTAA ALAELDVLSN LAERALNLDL NCPRFVAEPC MRIEQGRHPV VEQVLSTPFV
     ANDLALDDST RMLVITGPNM GGKSTYMRQT ALIVLLAHIG SFVPAASCEL SLVDRIFTRI
     GSSDDLAGGR STFMVEMSET ANILHNATDK SLVLMDEVGR GTSTFDGLSL AWAAAECLAQ
     LRAYTLFATH YFELTVLPES EPLVSNVHLN ATEHNERIVF LHRVLPGPAS QSYGLAVAQL
     AGVPGKVISR AKEHLQRLET TSLPHEQPRA KPGKPAVPQQ SDMFASLPHP VLDELSKVKV
     DDMTPRQALD LLYTLQTRL