ID   MUTS_PSEA6              Reviewed;         889 AA.
AC   Q15QR9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Patl_3263;
OS   Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Pseudoalteromonadaceae; Pseudoalteromonas.
OX   NCBI_TaxID=342610;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T6c / ATCC BAA-1087;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Karls A.C.,
RA   Bartlett D., Higgins B.P., Richardson P.;
RT   "Complete sequence of Pseudoalteromonas atlantica T6c.";
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000388; ABG41769.1; -; Genomic_DNA.
DR   RefSeq; WP_011575999.1; NC_008228.1.
DR   AlphaFoldDB; Q15QR9; -.
DR   SMR; Q15QR9; -.
DR   STRING; 342610.Patl_3263; -.
DR   EnsemblBacteria; ABG41769; ABG41769; Patl_3263.
DR   KEGG; pat:Patl_3263; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001981; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..889
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335203"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         640..647
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   889 AA;  99158 MW;  B6A63573F54B00E3 CRC64;
     MPKTNSSAAS TNANPSSLQQ HTPMMQQYLK IKAEHPDILL FYRMGDFYEL FFDDAKKAAE
     LLDISLTARG KSGGNAIPMA GVPYHAVENY LARLVKMGQS VAIVEQVGDP ATSKGPVERK
     VQRIVTPGTV SDEALLNDKQ DSILAAVFCP TQKANQELIF GYATLDVTSG RFTLCELSGE
     EALAAELQRT NPVELLYPDD FAYSHLINQR KGLRRRPQWE FDLQTATNQL TSQFGTNELS
     GFGVQNHQVG ICAAGCVMQY IKDTQRSALP HIDRIVLESH NDTVVMDAAT RRNLELTFNL
     SGGIENTLAS ILDKTSTPMG SRLLQRWIHR PLTDVTVLKK RQRNIQGLME SPYTQLQSAL
     KKIGDMQRVL ARLALRSARP RDFARLRQAF ALLPDIQHYL EHEISHTSES AQPSDLLHLA
     EKISQYPDFA DLLERAVIEA PPVLIRDGGV IKEGYNEELD RLRELSKGAT DYLEELELRE
     KERTGIASLK VGYNRVHGYF IEVSRSQSDL VPVEYVRRQT LKNNERYIIP ELKEHEDNVL
     SSQSRSLALE KRLYDELFDL LLPQLTQLMQ SADALAELDV LTNLAERAES LDYHRPELCP
     QSGIHFSQGR HPVVEQVSDA PFIANPINVN PDRRMLVITG PNMGGKSTYM RQTALIVLMA
     YIGSYIPAQD AQIGPIDRIF TRIGASDDLA SGRSTFMVEM TETANILNNA TANSLVLMDE
     IGRGTSTYDG LSLAWACAEY LATKLQSFTL FATHYFELTG LADALPELAN VHLDAVEHGE
     SIRFMHAVQD GAANKSYGLQ VAQLAGVPKL VVQAAKRKLH ELETGDISKQ GRQETSPVNT
     VYATEKVETQ LDLLSQTSEA EDLLHSIQPD DLTPKQALDY LYQLKKLVR