ID   MUTS_PSEA7              Reviewed;         855 AA.
AC   A6V1G8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=PSPA7_1519;
OS   Pseudomonas aeruginosa (strain PA7).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=381754;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PA7;
RA   Dodson R.J., Harkins D., Paulsen I.T.;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000744; ABR81120.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6V1G8; -.
DR   SMR; A6V1G8; -.
DR   EnsemblBacteria; ABR81120; ABR81120; PSPA7_1519.
DR   KEGG; pap:PSPA7_1519; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001582; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..855
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008079"
FT   REGION          795..816
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        799..815
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   855 AA;  94962 MW;  CFF4D191C3A5E50C CRC64;
     MTDLSQHTPM MQQYFKLKHQ HPDQLMFYRM GDFYELFYED AKKAAKLLDI TLTARGQSGG
     KAIPMAGIPF HSAEGYLAKL VKLGESVAIC EQIGDPATSK GPVERQVVRI ITPGTVSDEA
     LLDERRDNLL AAILGDERLF GLAVLDITSG RFSVQEIKGW ETLLAELERL NPAELLIPDD
     WPQGLPAEKR RGVRRRAPWD FDRDSAHKSL CQQFGTQDLK GFGCQNLTLA IGAAGCLLAY
     AKETQRTALP HLRSLRHDRL DDTVILDGAS RRNLELDINL SGGRENTLQS VVDRCQTAMA
     SRLMSRWLNR PLRDRAVLEA RQESIACLLE RYRFENLQPQ LKEIGDLERI LARIGLRNAR
     PRDLARLRDA LAALPDLQNA MTELEAPHLQ ALATTIGTYP ELAELLAKAI IDNPPAVIRD
     GGVIKTGYDA ELDELQALSE NAGQFLMDLE AREKARTGLP NLKVGYNRIH GYFIELPRVQ
     AEQAPADYIR RQTLKGAERF ITPELKAFED KALSAQSRAL AREKALYEEL LERLIGHLAP
     LQDSASALAE LDVLANLAER ALNLDLNRPR FVEHTCLHIE QGRHPVVEQV LETPFVANDL
     ALDADTRMLV ITGPNMGGKS TYMRQTALIV LLAHIGSFVP AARCELSLVD RIFTRIGSSD
     DLAGGRSTFM VEMSETANIL HNATDKSLVL MDEVGRGTST FDGLSLAWAA AEDLARTRAF
     TLFATHYFEL TVLPESQPAV ANVHLNATEH NERIVFLHHV LPGPASQSYG LAVAQLAGVP
     SPVIQRAREH LKRLETTSLP HEVPSQQSGK PASPMQSDLF ASLPHPVIDE LSRINPDDIS
     PRQALDLLYA WKMRV