MUTS_PSEAE
ID MUTS_PSEAE Reviewed; 855 AA.
AC Q9HY08; Q9L7T5; Q9LAN6;
DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=PA3620;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Hex1T;
RA Pezza R.J., Smania A.M., Argarana C.E.;
RT "Cloning and nucleotide sequence of Pseudomonas aeruginosa MutS gene.";
RL Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RA Blazquez J.;
RT "Cloning and sequencing of mutS gene from Pseudomonas aeruginosa.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF126491; AAF36440.1; -; Genomic_DNA.
DR EMBL; AF220055; AAF42850.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG07008.1; -; Genomic_DNA.
DR PIR; B83193; B83193.
DR RefSeq; NP_252310.1; NC_002516.2.
DR RefSeq; WP_003113873.1; NZ_QZGE01000001.1.
DR AlphaFoldDB; Q9HY08; -.
DR SMR; Q9HY08; -.
DR STRING; 287.DR97_4319; -.
DR PaxDb; Q9HY08; -.
DR PRIDE; Q9HY08; -.
DR EnsemblBacteria; AAG07008; AAG07008; PA3620.
DR GeneID; 880229; -.
DR KEGG; pae:PA3620; -.
DR PATRIC; fig|208964.12.peg.3789; -.
DR PseudoCAP; PA3620; -.
DR HOGENOM; CLU_002472_4_0_6; -.
DR InParanoid; Q9HY08; -.
DR OMA; TPMMAQY; -.
DR PhylomeDB; Q9HY08; -.
DR BioCyc; PAER208964:G1FZ6-3689-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..855
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000115121"
FT REGION 796..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..815
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 613..620
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
FT CONFLICT 649..650
FT /note="VD -> AV (in Ref. 1; AAF36440)"
FT /evidence="ECO:0000305"
FT CONFLICT 781
FT /note="A -> T (in Ref. 1; AAF36440)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 855 AA; 94978 MW; D4F4C75D09A329C6 CRC64;
MTDLSQHTPM MQQYFKLKHQ HPDQLMFYRM GDFYELFYED AKKAAKLLDI TLTARGQSGG
KAIPMAGIPF HSAEGYLAKL VKLGESVAIC EQIGDPATSK GPVERQVVRI ITPGTVSDEA
LLDERRDNLL AAILGDERLF GLAVLDITSG RFSVQEIKGW ETLLAELERL NPAELLIPDD
WPQGLPAEKR RGVRRRAPWD FDRDSAHKSL CQQFGTQDLK GFGCQNLTLA IGAAGCLLAY
AKETQRTALP HLRSLRHDRL DDTVILDGAS RRNLELDINL SGGRENTLQS VVDRCQTAMA
SRLMSRWLNR PLRDRAVLEA RQESIACLLE RYRFENLQPQ LKEIGDLERI LARIGLRNAR
PRDLARLRDA LAALPDLQNA MTELEAPHLQ ALATTIGTYP ELAELLAKAI IDNPPAVIRD
GGVIKTGYDA ELDELQALSE NAGQFLMDLE AREKARTGLP NLKVGYNRIH GYFIELPRVQ
AEQAPADYIR RQTLKGAERF ITPELKAFED KALSAQSRAL AREKALYEEL LERLIGHLAP
LQDSASALAE LDVLANLAER ALNLDLNRPR FVEHTCLHIE QGRHPVVEQV LETPFVANDL
ALDADTRMLV ITGPNMGGKS TYMRQTALIV LLAHIGSFVP AARCELSLVD RIFTRIGSSD
DLAGGRSTFM VEMSETANIL HNATDKSLVL MDEVGRGTST FDGLSLAWAA AEDLARTRAF
TLFATHYFEL TVLPESQPAV ANVHLNATEH NERIVFLHHV LPGPASQSYG LAVAQLAGVP
APVIQRAREH LKRLETTSLP HEMPSQQSGK PASPMQSDLF ASLPHPVIDE LSRINPDDIS
PRQALDLLYA WKMRV
