ID   MUTS_PSEE4              Reviewed;         857 AA.
AC   Q1I659;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=PSEEN4187;
OS   Pseudomonas entomophila (strain L48).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=384676;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L48;
RX   PubMed=16699499; DOI=10.1038/nbt1212;
RA   Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C.,
RA   Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P.,
RA   Weissenbach J., Lemaitre B., Medigue C., Boccard F.;
RT   "Complete genome sequence of the entomopathogenic and metabolically
RT   versatile soil bacterium Pseudomonas entomophila.";
RL   Nat. Biotechnol. 24:673-679(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CT573326; CAK16876.1; -; Genomic_DNA.
DR   RefSeq; WP_011535247.1; NC_008027.1.
DR   AlphaFoldDB; Q1I659; -.
DR   SMR; Q1I659; -.
DR   STRING; 384676.PSEEN4187; -.
DR   EnsemblBacteria; CAK16876; CAK16876; PSEEN4187.
DR   KEGG; pen:PSEEN4187; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000658; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..857
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008081"
FT   REGION          794..816
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   857 AA;  94914 MW;  3E35624AA13C153A CRC64;
     MSDLSAHTPM MQQYWKLKHQ HPDQLMFYRM GDFYEIFYED AKKAAKLLDI TLTARGQSAG
     QSIPMCGIPF HSLEGYLAKL VKLGESVVIC EQIGDPATSK GPVERQVVRI ITPGTISDEA
     LLDERRDNLI AALLGDERLF GLAVLDITSG NFTVQEIKGW ENLLAELERI NPVELLIPDD
     WPQGLPAEKR PGARRRAPWD FDRDTARKSL CQQFATQDLK GFGCDKLTLA IGAAGCLLGY
     AKETQRTALP HLRSLRHERM DDTVILDAAS RRNLELDINL AGGRDNTLQS VIDRCQTAMA
     SRLLTRWLNR PLRDLKVLKA RQDSIRCLLD GYRFEKLQPQ LKEIGDIERI LARIGLRNAR
     PRDLARLRDA LGALPELQNA MAELEAPHLA RLAAITGTYP ELAGLLERAI IDNPPAVIRD
     GGVLKTGYDS ELDELLAMSE NAGQFLIDLE AREKARTGLA NLKVGYNRVH GYYIELPTKQ
     AEQAPGDYIR RQTLKGAERF ITPELKAFED KALSAKSRAL AREKMLYDAL LETLIGHLAP
     LQDSAAALAE LDVLSNLAER ALNLDLNCPS FVDEPCLRIE QGRHPVVEQV LTTPFVANDL
     GLDNSTRMLI ITGPNMGGKS TYMRQTALIV LMAHIGSFVP AARCELSLVD RIFTRIGSSD
     DLAGGRSTFM VEMSETANIL HNATDCSLVL MDEVGRGTST FDGLSLAWAA AERLAQLRAY
     TLFATHYFEL TVLPESEPLV ANVHLNATEH NERIVFLHHV LPGPASQSYG LAVAQLAGVP
     AVVIQRAREH LGRLETTSLP HETPIASKSK GEPDVPHQSD LFASLPHPAI EKLGKLDLDD
     MTPRQAIETL YQLKNLL