ID   MUTS_PSEF5              Reviewed;         859 AA.
AC   Q4KHE3;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=PFL_1209;
OS   Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=220664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-477 / NRRL B-23932 / Pf-5;
RX   PubMed=15980861; DOI=10.1038/nbt1110;
RA   Paulsen I.T., Press C.M., Ravel J., Kobayashi D.Y., Myers G.S.A.,
RA   Mavrodi D.V., DeBoy R.T., Seshadri R., Ren Q., Madupu R., Dodson R.J.,
RA   Durkin A.S., Brinkac L.M., Daugherty S.C., Sullivan S.A., Rosovitz M.J.,
RA   Gwinn M.L., Zhou L., Schneider D.J., Cartinhour S.W., Nelson W.C.,
RA   Weidman J., Watkins K., Tran K., Khouri H., Pierson E.A., Pierson L.S. III,
RA   Thomashow L.S., Loper J.E.;
RT   "Complete genome sequence of the plant commensal Pseudomonas fluorescens
RT   Pf-5.";
RL   Nat. Biotechnol. 23:873-878(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000076; AAY90496.1; -; Genomic_DNA.
DR   RefSeq; WP_011059556.1; NC_004129.6.
DR   AlphaFoldDB; Q4KHE3; -.
DR   SMR; Q4KHE3; -.
DR   STRING; 220664.PFL_1209; -.
DR   EnsemblBacteria; AAY90496; AAY90496; PFL_1209.
DR   GeneID; 57474213; -.
DR   KEGG; pfl:PFL_1209; -.
DR   PATRIC; fig|220664.5.peg.1241; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000008540; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..859
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224392"
FT   REGION          801..820
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         617..624
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   859 AA;  95192 MW;  782D989A0F9E13C4 CRC64;
     MSKNTSDLSS HTPMMQQYWR LKNQHPDQLM FYRMGDFYEI FYEDAKKAAK LLDITLTARG
     QSAGQAIPMC GIPYHAAEGY LAKLVKLGES VVICEQVGDP ATSKGPVERQ VVRIITPGTV
     SDEALLDERR DNLIAAVLGD ERLFGLAVLD ITSGNFSVLE IKGWENLLAE LERINPVELL
     IPDDWPQGLP AEKRRGVRRR APWDFERDSA HKSLCQQFST QDLKGFGCET LTLAIGAAGC
     LLSYAKETQR TALPHLRSLR HERLDDTVVL DGASRRNLEL DTNLAGGRDN TLQSVVDRCQ
     TAMGSRLLTR WLNRPLRDLK VLEARQSSIT CLLDGYRFER LQPQLKEIGD IERILARIGL
     RNARPRDLAR LRDALAALPE LQEAMTELEA THLNQLAATT STYPELAALL AKAIIDNPPA
     VIRDGGVLKT GYDAELDELQ SLSENAGQFL IDLEAREKAR TGLANLKVGY NRIHGYFIEL
     PSKQAEQAPA DYIRRQTLKG AERFITPELK EFEDKALSAK SRALAREKML YDALLETLIS
     HLPPLQDTAG ALAELDVLSN LAERALNLDL NCPRFVSEPC MRITQGRHPV VEQVLTTPFV
     ANDLSLDDNT RMLVITGPNM GGKSTYMRQT ALIVLLAHIG SFVPAASCEL SLVDRIFTRI
     GSSDDLAGGR STFMVEMSET ANILHNATER SLVLMDEVGR GTSTFDGLSL AWAAAERLAH
     LRAYTLFATH YFELTVLPES EPLVANVHLN ATEHNERIVF LHHVLPGPAS QSYGLAVAQL
     AGVPSAVITR AREHLSRLET TSLPHEVAPQ APGKPSVPQQ SDMFASLPHP VLDDLAKLDL
     DDMTPRRALE MLYTLKTRI