ID   MUTS_PSEFS              Reviewed;         863 AA.
AC   C3KCT2;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=PFLU_1164;
OS   Pseudomonas fluorescens (strain SBW25).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=216595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SBW25;
RX   PubMed=19432983; DOI=10.1186/gb-2009-10-5-r51;
RA   Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R.,
RA   Jackson R.W., Preston G.M., Zhang X.-X., Moon C.D., Gehrig S.M.,
RA   Godfrey S.A.C., Knight C.G., Malone J.G., Robinson Z., Spiers A.J.,
RA   Harris S., Challis G.L., Yaxley A.M., Harris D., Seeger K., Murphy L.,
RA   Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K.,
RA   Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M.,
RA   Parkhill J., Levy S.B., Rainey P.B., Thomson N.R.;
RT   "Genomic and genetic analyses of diversity and plant interactions of
RT   Pseudomonas fluorescens.";
RL   Genome Biol. 10:R51.1-R51.16(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AM181176; CAY47426.1; -; Genomic_DNA.
DR   RefSeq; WP_012722497.1; NC_012660.1.
DR   AlphaFoldDB; C3KCT2; -.
DR   SMR; C3KCT2; -.
DR   STRING; 294.SRM1_01162; -.
DR   PRIDE; C3KCT2; -.
DR   EnsemblBacteria; CAY47426; CAY47426; PFLU_1164.
DR   KEGG; pfs:PFLU_1164; -.
DR   PATRIC; fig|216595.4.peg.1398; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002332; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..863
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000202742"
FT   BINDING         617..624
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   863 AA;  95596 MW;  181127ECF5E0E409 CRC64;
     MSKNTSDLSS HTPMMQQYWR LKNQHPDQLM FYRMGDFYEI FYEDAKKAAK LLDITLTARG
     QSAGQSIPMC GIPYHSLEGY LVKLVKLGES VVICEQIGDP ATSKGPVERQ VVRIITPGTV
     SDEALLDERR DNLIAAVLGD ERLFGLSVLD ITSGNFSVLE IKGWENLLAE LERINPVELL
     IPDDWPKDLP AEKRRGTKRR APWDFERDSA LKSLCQQFSV QDLKGFGCET LTLAIGAAGC
     LLGYAKETQR TALPHLRSLR HERLDDTVVL DGASRRNLEL DTNLAGGRDN TLQSVVDRCQ
     TAMGSRLLTR WLNRPLRDLT VLQARQTSIT CLLDGYRFEK LQPQLKEIGD IERILARIGL
     RNARPRDLAR LRDALGALPQ LQVAMTELDT PHLQQLAVTA GTYPELAALL EKAIIDNPPA
     IIRDGGVLKT GYDSELDELQ SLSENAGQFL IDLEAREKAR TGLANLKVGY NRVHGYFIEL
     PSKQAESAPI DYQRRQTLKG AERFITPELK AFEDKALSAK SRALAREKML YEALLEDLIS
     QLAPLQDTAA ALAELDVLSN LAERALNLDL NCPRFVSEPC MRIVQGRHPV VEQVLTTPFV
     ANDLSLDDDT RMLVITGPNM GGKSTYMRQT ALIVLLAHIG SFVPAASCEL SLVDRIFTRI
     GSSDDLAGGR STFMVEMSET ANILHNATER SLVLMDEVGR GTSTFDGLSL AWAAAERLAH
     LRAYTLFATH YFELTVLPES EPLVTNVHLN ATEHNERIVF LHHVLPGPAS QSYGLAVAQL
     AGVPNDVITR AREHLSRLET TALPHETVVA SPTKATSKPA APHQSDMFAS LPHPVLDELA
     KLDLDGLTPR KALEMLYALQ VRI