ID   MUTS_PSELT              Reviewed;         811 AA.
AC   A8F753;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Tlet_1431;
OS   Pseudothermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / NBRC 107922 /
OS   TMO) (Thermotoga lettingae).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Pseudothermotoga.
OX   NCBI_TaxID=416591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Foster B., Bruce D., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Nelson K., Gogarten J.P., Noll K.,
RA   Richardson P.;
RT   "Complete sequence of Thermotoga lettingae TMO.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000812; ABV33987.1; -; Genomic_DNA.
DR   RefSeq; WP_012003463.1; NC_009828.1.
DR   AlphaFoldDB; A8F753; -.
DR   SMR; A8F753; -.
DR   STRING; 416591.Tlet_1431; -.
DR   EnsemblBacteria; ABV33987; ABV33987; Tlet_1431.
DR   KEGG; tle:Tlet_1431; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_0; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002016; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..811
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000057638"
FT   BINDING         595..602
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   811 AA;  92164 MW;  1A4A0BA72C980DED CRC64;
     MKLTPMMQQY MDIKSKYKDA ILLFRLGDFY EAFFEDAEIV SKTLDLVLTH RQDAPMAGVP
     YHALNTYLKK LVQFGYKVAI CDQVEDPSTA KGLVKREVTR IVTPGTVLED DLLDQNSNNY
     LVAICRKSEY SVAGVDISTG ESFVVSFKDF QSMIDFLGSV KVSQVLCEPD LRQDLEKNLA
     DIMIESLADW HLDDALLEKD IAEVFKVSDI DHLELGSNLK VFGALVRYLR YTLMSPCTLV
     KPPRIIRDQM YVFLDPATIE HLSLVGGEKG KNLFDVLNHT KTSMGSRLLK NWILQPLRDL
     YEINKRLDKV QAFVEDSILL NEIREYLQAV RDIQRIANRI NYGKASVKDL VALRSTLQVC
     PYIKEVLLTN EAFPEAAMVD CLHDICEILN DAIKEEPSSV IGEGKVIKEG YDEQLDQLRE
     LVYHSQEFLN NFEQRERDRT GIPNLRVGYN SVFGYYIEIT KSHLSKIPPN YVRKQTLVNA
     ERFITDELKE FEQKMLTAKE NLERREKEIY DEICASLSSK VGLIIELAEF LAQIDVLSTL
     AYVAIRYGYT KPSFSNDGKL LLRNSRHPVV ERLVDTFVPN DLEMDRTKNF IILTGPNMSG
     KSTFIRQVAL VSIMAQMGSF VPADEAILPV FDRIFAKMGI RDDIASGKST FLIEMNEVAK
     IVYQATENSL ILLDEVGRGT STFDGISIAW AVSEYLQNQI SCKCIFATHF TELTELAKMY
     DGIVNKTVQV IEEKNQVIFL HRVVDGIADR SYGIEVAGIA GLPGEIIQRA REVLDVIANK
     SELEDKLRVI SSEKLKKLKK KKVHPNQAQL W