ID   MUTS_PSEP1              Reviewed;         857 AA.
AC   A5W816;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Pput_4152;
OS   Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=351746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700007 / DSM 6899 / BCRC 17059 / F1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Lykidis A., Parales R., Richardson P.;
RT   "Complete sequence of Pseudomonas putida F1.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000712; ABQ80276.1; -; Genomic_DNA.
DR   RefSeq; WP_012053533.1; NC_009512.1.
DR   AlphaFoldDB; A5W816; -.
DR   SMR; A5W816; -.
DR   STRING; 351746.Pput_4152; -.
DR   EnsemblBacteria; ABQ80276; ABQ80276; Pput_4152.
DR   KEGG; ppf:Pput_4152; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..857
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008082"
FT   REGION          797..820
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   857 AA;  95101 MW;  60FCE7C3BA474F15 CRC64;
     MSSLSDHTPM MQQYWKLKNQ HPDQLMFYRM GDFYEIFYED AKKAAKLLDI TLTARGQSAG
     QSIPMCGIPF HSLEGYLAKL VKLGESVVIC EQIGDPATSK GPVERQVVRI ITPGTVSDEA
     LLDERRDNLI AALLGDERLF GLAVLDITSG NFSVQEIKGW ENLLAELERL NPVELLIPDD
     WPRDLPAEKR PGARRRAPWD FDRDSARKAL CQQFATKDLK GFGCDKLTLA IGAAGCLLTY
     AKETQRTALP HLRSLRHERL DDTVILDGAS RRNLELDINL AGGRDNTLQS VIDRCQTAMA
     SRLLSRWLNR PLRDLKVLQA RQDSIRCLLD SYRFEKLQPQ LKEIGDIERI LARIGLRNAR
     PRDLARLRDA LGALPELQNA MTELEAPHLA RLAAITGTYP ELASLLERAI IDNPPAVIRD
     GGVLKAGYDN ELDELLAISE NAGQFLIDLE AREKARTGLA NLKVGYNRVH GYFIELPTKQ
     AEQAPGDYIR RQTLKGAERF ITPELKAFED KALSAKSRAL AREKMLYDAL LETLISHLAP
     LQDSAAALAE LDVLSNLAER ALNLDLSCPR FVDEPCLRIE QGRHPVVEQV LTTPFVANDL
     GLDNSTRMLI ITGPNMGGKS TYMRQTALIV LLAHIGSFVP AASCELSLVD RIFTRIGSSD
     DLAGGRSTFM VEMSETANIL HNATDRSLVL MDEVGRGTST FDGLSLAWAA AERLAQLRAY
     TLFATHYFEL TVLPESEPLV ANVHLNATEH NERIVFLHHV LPGPASQSYG LAVAQLAGVP
     TAVIQRAREH LGRLETTSLP HEQPAAHKAK DAPQVPHQSD LFASLPHPAI EKLGKLQLDD
     MTPRQAIEML YQLKNLL