ID   MUTS_PSEPF              Reviewed;         860 AA.
AC   Q3KH79;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Pfl01_1134;
OS   Pseudomonas fluorescens (strain Pf0-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=205922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pf0-1;
RX   PubMed=19432983; DOI=10.1186/gb-2009-10-5-r51;
RA   Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R.,
RA   Jackson R.W., Preston G.M., Zhang X.-X., Moon C.D., Gehrig S.M.,
RA   Godfrey S.A.C., Knight C.G., Malone J.G., Robinson Z., Spiers A.J.,
RA   Harris S., Challis G.L., Yaxley A.M., Harris D., Seeger K., Murphy L.,
RA   Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K.,
RA   Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M.,
RA   Parkhill J., Levy S.B., Rainey P.B., Thomson N.R.;
RT   "Genomic and genetic analyses of diversity and plant interactions of
RT   Pseudomonas fluorescens.";
RL   Genome Biol. 10:R51.1-R51.16(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000094; ABA72877.1; -; Genomic_DNA.
DR   RefSeq; WP_011332706.1; NC_007492.2.
DR   AlphaFoldDB; Q3KH79; -.
DR   SMR; Q3KH79; -.
DR   STRING; 205922.Pfl01_1134; -.
DR   PRIDE; Q3KH79; -.
DR   EnsemblBacteria; ABA72877; ABA72877; Pfl01_1134.
DR   KEGG; pfo:Pfl01_1134; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002704; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..860
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224393"
FT   REGION          800..823
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         617..624
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   860 AA;  95263 MW;  FBD7CDA0F1AD29BB CRC64;
     MNKAVSDLSS HTPMMQQYWR LKNQHPDQLM FYRMGDFYEI FYEDAKKAAK LLDITLTARG
     QSAGQAIPMC GIPYHAAEGY LAKLVKLGES VVICEQVGDP ATSKGPVERQ VVRIITPGTV
     SDEALLDERR DNLIAAVLGD ERLFGLAVLD ITSGNFTVLE IKGWENLLAE LERVNPVELL
     IPDDWPKDLP AEKRRGVRRR APWDFERDSA LKSLCQQFST QDLKGFGCET LTLAIGAAGC
     LLAYAKETQR TALPHLRSLR HERLDDTVVL DGASRRNLEL DTNLAGGRDN TLQSVVDRCQ
     TAMGSRLLTR WLNRPLRDLT VLLARQTSIT CLLDRYRFEN LQPQLKEIGD IERILARIGL
     RNARPRDLAR LRDALGALPE LQVAMTDLEA PHLQRLATTT STYPELAALL EKAIIDNPPA
     VIRDGGVLKT GYDSELDELQ SLSENAGQFL IDLEAREKAR TGLANLKVGY NRIHGYFIEL
     PSKQAESAPA DYIRRQTLKG AERFITPELK EFEDKALSAK SRALAREKML YEALLEDLIS
     QLPPLQDTAG ALAELDVLSN LAERALNLDL NCPTFVSEPC MRISQGRHPV VEQVLTTPFV
     ANDLSLDDNT RMLVITGPNM GGKSTYMRQT ALIVLLAHIG SFVPAASCEL SLVDRIFTRI
     GSSDDLAGGR STFMVEMSET ANILHNATER SLVLMDEVGR GTSTFDGLSL AWAAAERLAQ
     LRAYTLFATH YFELTVLPEA EPLVANVHLN ATEHNERIVF LHHVLPGPAS QSYGLAVAQL
     AGVPSEVIVR AREHLSRLED TALPHEAPKP AAKGKPAAPQ QSDMFASLPH PVLDELAKLD
     LDDVTPRRAL EMLYALKNRI