ID   MUTS_PSEPK              Reviewed;         857 AA.
AC   Q88ME7;
DT   24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=PP_1626;
OS   Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950
OS   / KT2440).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=160488;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440;
RX   PubMed=12534463; DOI=10.1046/j.1462-2920.2002.00366.x;
RA   Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H.,
RA   Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M.,
RA   Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F.,
RA   Madupu R., Nelson W.C., White O., Peterson J.D., Khouri H.M., Hance I.,
RA   Chris Lee P., Holtzapple E.K., Scanlan D., Tran K., Moazzez A.,
RA   Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D., Wedler H.,
RA   Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S., Kiewitz C.,
RA   Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B., Fraser C.M.;
RT   "Complete genome sequence and comparative analysis of the metabolically
RT   versatile Pseudomonas putida KT2440.";
RL   Environ. Microbiol. 4:799-808(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE015451; AAN67247.1; -; Genomic_DNA.
DR   RefSeq; NP_743783.1; NC_002947.4.
DR   RefSeq; WP_010952693.1; NC_002947.4.
DR   AlphaFoldDB; Q88ME7; -.
DR   SMR; Q88ME7; -.
DR   STRING; 160488.PP_1626; -.
DR   EnsemblBacteria; AAN67247; AAN67247; PP_1626.
DR   KEGG; ppu:PP_1626; -.
DR   PATRIC; fig|160488.4.peg.1718; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   PhylomeDB; Q88ME7; -.
DR   BioCyc; PPUT160488:G1G01-1724-MON; -.
DR   Proteomes; UP000000556; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..857
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115122"
FT   REGION          797..820
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   857 AA;  95112 MW;  AEF2CF4603E49499 CRC64;
     MSDLSAHTPM MQQYWKLKNQ HPDQLMFYRM GDFYEIFYED AKKAAKLLDI TLTARGQSAG
     QSIPMCGIPF HSLEGYLAKL VKLGESVVIC EQIGDPATSK GPVERQVVRI ITPGTVSDEA
     LLDERRDNLI AALLGDERLF GLAVLDITSG NFSVQEIKGW ENLLAELERL NPVELLIPDD
     WPRDLPAEKR PGARRRAPWD FDRDSARKAL CQQFATKDLK GFGCDKLTLA IGAAGCLLTY
     AKETQRTALP HLRSLRHERL DDTVILDGAS RRNLELDINL AGGRDNTLQS VIDRCQTAMA
     SRLLSRWLNR PLRDLKVLQA RQDSIRCLLD SYRFEKLQPQ LKEIGDIERI LARIGLRNAR
     PRDLARLRDA LGALPELQNA MTELEAPHLA RLAAITGTYP ELASLLERAI IDNPPAVIRD
     GGVLKAGYDN ELDELLAISE NAGQFLIDLE AREKARTGLA NLKVGYNRVH GYFIELPTKQ
     AEQAPGDYIR RQTLKGAERF ITPELKAFED KALSAKSRAL AREKMLYDAL LETLISHLAP
     LQDSAAALAE LDVLSNLAER ALNLDLNCPR FVDEPCLRIE QGRHPVVEQV LTTPFVANDL
     GLDNSTRMLI ITGPNMGGKS TYMRQTALIV LLAHIGSFVP AASCELSLVD RIFTRIGSSD
     DLAGGRSTFM VEMSETANIL HNATDRSLVL MDEVGRGTST FDGLSLAWAA AERLAQLRAY
     TLFATHYFEL TVLPESEPLV ANVHLNATEH NERIVFLHHV LPGPASQSYG LAVAQLAGVP
     TAVIQRAREH LGRLETTSLP HEQPAAHKAK DAPQVPHQSD LFASLPHPAI EKLGKLQLDD
     MTPRQAIEML YQLKNLL