ID   MUTS_PSEPW              Reviewed;         857 AA.
AC   B1JB25;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=PputW619_4050;
OS   Pseudomonas putida (strain W619).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=390235;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=W619;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S.,
RA   Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Taghavi S., Vangronsveld D., van der Lelie D.,
RA   Richardson P.;
RT   "Complete sequence of Pseudomonas putida W619.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000949; ACA74530.1; -; Genomic_DNA.
DR   RefSeq; WP_012315870.1; NC_010501.1.
DR   AlphaFoldDB; B1JB25; -.
DR   SMR; B1JB25; -.
DR   STRING; 390235.PputW619_4050; -.
DR   EnsemblBacteria; ACA74530; ACA74530; PputW619_4050.
DR   KEGG; ppw:PputW619_4050; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..857
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093638"
FT   REGION          795..823
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   857 AA;  95052 MW;  F9F9FED254B538BB CRC64;
     MSDLSAHTPM MQQYWKLKNQ HPDQLMFYRM GDFYEIFYED AKKAAKLLDI TLTARGQSAG
     QSIPMCGIPF HSLEGYLAKL VKLGESVVIC EQIGDPATSK GPVERQVVRI ITPGTVSDEA
     LLDERRDNLI AALLGDERLF GLAVLDITSG NFSVQEIKGW ENLLAELERI NPVELLIPDD
     WPRDLPAEKR PGARRRAPWD FDRDSARKAL CQQFATKDLK GFGCDKLTLA IGAAGCLLTY
     AKETQRTALP HLRSLRHERL DDTVILDGAS RRNLELDINL AGGRDNTLQS VIDRCQTAMA
     SRLLTRWLNR PLRDLKVLQA RQDSIRCLLD GYRFEKLQPQ LKEIGDIERI LARIGLRNAR
     PRDLARLRDA LGALPELQNA MAELEAPHLA RLAAITGTYP ELASLLERAI IDNPPAVIRD
     GGVLKAGYDN ELDDLLAISE NAGQFLIDLE AREKARTGLA NLKVGYNRVH GYFIELPTKQ
     AEQAPGDYIR RQTLKGAERF ITPELKAFED KALSAKSRAL AREKMLYDAL LETLISHLAP
     LQDSAAALAE LDVLSNLAER ALNLDLNCPR FVDEPCLRID QGRHPVVEQV LTTPFVANDL
     GLDNSTRMLI ITGPNMGGKS TYMRQTALIV LMAHIGSFVP AASCELSLVD RIFTRIGSSD
     DLAGGRSTFM VEMSETANIL HNATDRSLVL MDEVGRGTST FDGLSLAWAA AERLAQLRAY
     TLFATHYFEL TVLPESEPLV ANVHLNATEH NERIVFLHHV LPGPASQSYG LAVAQLAGVP
     SPVIQRAREH LGRLETSSLP HEQAVSKKTK GEPQAPHQSD LFASLPHPAI EKLGKLDLDD
     MTPRQAIEML YQLKNLL