ID   MUTS_PSESM              Reviewed;         855 AA.
AC   Q87XW6;
DT   24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=PSPTO_4058;
OS   Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=223283;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-871 / DC3000;
RX   PubMed=12928499; DOI=10.1073/pnas.1731982100;
RA   Buell C.R., Joardar V., Lindeberg M., Selengut J., Paulsen I.T.,
RA   Gwinn M.L., Dodson R.J., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Daugherty S.C., Brinkac L.M., Beanan M.J., Haft D.H., Nelson W.C.,
RA   Davidsen T.M., Zafar N., Zhou L., Liu J., Yuan Q., Khouri H.M.,
RA   Fedorova N.B., Tran B., Russell D., Berry K.J., Utterback T.R.,
RA   Van Aken S.E., Feldblyum T.V., D'Ascenzo M., Deng W.-L., Ramos A.R.,
RA   Alfano J.R., Cartinhour S., Chatterjee A.K., Delaney T.P., Lazarowitz S.G.,
RA   Martin G.B., Schneider D.J., Tang X., Bender C.L., White O., Fraser C.M.,
RA   Collmer A.;
RT   "The complete genome sequence of the Arabidopsis and tomato pathogen
RT   Pseudomonas syringae pv. tomato DC3000.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10181-10186(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016853; AAO57515.1; -; Genomic_DNA.
DR   RefSeq; NP_793820.1; NC_004578.1.
DR   RefSeq; WP_011104855.1; NC_004578.1.
DR   AlphaFoldDB; Q87XW6; -.
DR   SMR; Q87XW6; -.
DR   STRING; 223283.PSPTO_4058; -.
DR   EnsemblBacteria; AAO57515; AAO57515; PSPTO_4058.
DR   GeneID; 1185738; -.
DR   KEGG; pst:PSPTO_4058; -.
DR   PATRIC; fig|223283.9.peg.4161; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   PhylomeDB; Q87XW6; -.
DR   Proteomes; UP000002515; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..855
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115123"
FT   REGION          796..817
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   855 AA;  95201 MW;  FDB226A15907BC82 CRC64;
     MTDLSQHTPM MQQYWKLKNQ HLDQLMFYRM GDFYEIFYED AKKAAKLLDI TLTARGQSAG
     QSIPMCGIPY HAAEGYLAKL VKLGESVVIC EQIGDPATSK GPVDRQVVRI ITPGTISDEA
     LLDERRDNLI AAVLGDERLF GLAVLDITSG NFSVLEIKGW ENLLAELERI NPVELLIPDD
     WPQGLPAEKR RGARRRAPWD FERDSAHKSL CQQFSTQDLK GFGCETLTLA IGAAGCLLGY
     AKETQRTALP HLRSLRHERL DDTVILDAAS RRNLELDTNL SGGRDNTLQS VMDRCQTAMG
     TRLLTRWLNR PLRDLSILQA RQTSITCFLE RYRFENLQPQ LKEIGDIERI LARIGLRNAR
     PRDLARLRDA LSALPELQQA MTDLDAPHLQ QLAQTASTYP ELADLLQRAI NDNPPAVIRD
     GGVLKTGYDA ELDELQSLSE NAGQFLIDLE AREKARTGLS HLKVGYNRVH GYFIELPSKQ
     AEQAPADYIR RQTLKGAERF ITPELKEFED KALSAKSRAL AREKMLYETL LEDLIGHLAP
     LQDTAAALAE LDVLSNLAER ALNLDLNCPR FVAEPCMRIE QGRHPVVEQV LSTPFVANDL
     ALDDSTRMLI ITGPNMGGKS TYMRQTALIV LLAHIGSFVP AASCELSLVD RIFTRIGSSD
     DLAGGRSTFM VEMSETANIL HNATDKSLVL MDEVGRGTST FDGLSLAWAA AECLAQLRAY
     TLFATHYFEL TVLPESEPLV NNVHLNATEH NERIVFLHRV LPGPASQSYG LAVAQLAGVP
     GKVITRAKEH LQRLETTSLP HEQPRAKPGK PAIPQQSDMF ASLPHPVLDE LSKIKVDDMT
     PRQALDLLYT LQTRL