ID   MUTS_PSET1              Reviewed;         861 AA.
AC   Q3IDC8;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=PSHAa0692;
OS   Pseudoalteromonas translucida (strain TAC 125).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Pseudoalteromonadaceae; Pseudoalteromonas.
OX   NCBI_TaxID=326442;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TAC 125;
RX   PubMed=16169927; DOI=10.1101/gr.4126905;
RA   Medigue C., Krin E., Pascal G., Barbe V., Bernsel A., Bertin P.N.,
RA   Cheung F., Cruveiller S., D'Amico S., Duilio A., Fang G., Feller G., Ho C.,
RA   Mangenot S., Marino G., Nilsson J., Parrilli E., Rocha E.P.C., Rouy Z.,
RA   Sekowska A., Tutino M.L., Vallenet D., von Heijne G., Danchin A.;
RT   "Coping with cold: the genome of the versatile marine Antarctica bacterium
RT   Pseudoalteromonas haloplanktis TAC125.";
RL   Genome Res. 15:1325-1335(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CR954246; CAI85776.1; -; Genomic_DNA.
DR   RefSeq; WP_011327389.1; NC_007481.1.
DR   AlphaFoldDB; Q3IDC8; -.
DR   SMR; Q3IDC8; -.
DR   STRING; 326442.PSHAa0692; -.
DR   EnsemblBacteria; CAI85776; CAI85776; PSHAa0692.
DR   KEGG; pha:PSHAa0692; -.
DR   PATRIC; fig|326442.8.peg.655; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_1_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   BioCyc; PHAL326442:PSHA_RS03385-MON; -.
DR   Proteomes; UP000006843; Chromosome I.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..861
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224391"
FT   BINDING         621..628
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   861 AA;  95654 MW;  95402B2542FAC1DB CRC64;
     MSFDLYAPHT IKQQTPMMQQ YLKIKSEHRD ILLFYRMGDF YELFFDDAKR AAQLLDISQT
     QRGKAGGDPI PMAGVPYHAV ENYLARLVQM GESVAICEQV GDPATSKGPV DRKVVRIVTP
     GTISDEALLQ ERQDNLLTSV WQSKNGTYGI AYLDINSGRF NVVEVNTDEA FTSTIQRLAP
     AELLYSESFE NVHLIEHIKG ARRRPEWEFD LDTAQHLLCE QFGTKDLVGF GVDKAHCALV
     AAGCLMQYVK DTQRIALPHI RAITLEHNEH AVILDAATRK NLELTVNLSG GFENTLAQVL
     DKTATPMGSR LLKRRIHTPV RNKDELNSRL NAISAILDVQ LCGELHESLR EIGDVERVIA
     RLALCTARPR DLTRLRSALQ ALAPLHTLLN DASDPRIASI IKQSPELPDL QALLERAVIE
     NPPVLIRDGG VIAPGYNSEL DEWRNLSKGA TDVLDQLELR ERARTGISTL KIGYNRVHGF
     FIEVSRANAH LVPADYIRRQ TLKNNERYII PELKEHEDKV LGSQSKALAL EKQLYEELFR
     FIAPHIEQLQ IMAAALADLD VLNNLAERAL TLNYAKPILC DNDNISIKQG RHPVVEQVMK
     EPFIANPVEL NAQRKMLIIT GPNMGGKSTY MRQTALIVLM AHIGSYVPAD SAKIGNIDRI
     FTRIGASDDL ASGRSTFMVE MTETATILNN ATAQSLVLMD EIGRGTSTYD GLSLAYATAD
     HLASKISAKT LFATHYFELT ELAEQTPGLV NVHLDAIEHN DTIAFMHTVL DGAASKSFGL
     QVAALAGVPR SVINQAKQKL KLLENHQSVT APNIEQQAFT FNNQAQQISP SEVELQLTAI
     DPDNLSPRQA HDLLYKLKAL L