ID   MUTS_PSEU2              Reviewed;         859 AA.
AC   Q4ZWP5;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Psyr_1376;
OS   Pseudomonas syringae pv. syringae (strain B728a).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas; Pseudomonas syringae.
OX   NCBI_TaxID=205918;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B728a;
RX   PubMed=16043691; DOI=10.1073/pnas.0504930102;
RA   Feil H., Feil W.S., Chain P., Larimer F., Dibartolo G., Copeland A.,
RA   Lykidis A., Trong S., Nolan M., Goltsman E., Thiel J., Malfatti S.,
RA   Loper J.E., Lapidus A., Detter J.C., Land M., Richardson P.M.,
RA   Kyrpides N.C., Ivanova N., Lindow S.E.;
RT   "Comparison of the complete genome sequences of Pseudomonas syringae pv.
RT   syringae B728a and pv. tomato DC3000.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:11064-11069(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000075; AAY36427.1; -; Genomic_DNA.
DR   RefSeq; YP_234465.1; NC_007005.1.
DR   AlphaFoldDB; Q4ZWP5; -.
DR   SMR; Q4ZWP5; -.
DR   STRING; 205918.Psyr_1376; -.
DR   EnsemblBacteria; AAY36427; AAY36427; Psyr_1376.
DR   KEGG; psb:Psyr_1376; -.
DR   PATRIC; fig|205918.7.peg.1409; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000426; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..859
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224395"
FT   REGION          799..821
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         617..624
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   859 AA;  95401 MW;  7A6C1D750B3E2AA3 CRC64;
     MNKAISDLSA HTPMMQQYWK LKNQHLDQLM FYRMGDFYEI FYEDAKKAAK LLDITLTARG
     QSAGQSIPMC GIPYHAAEGY LAKLVKLGES VVICEQIGDP ATSKGPVDRQ VVRIITPGTI
     SDEALLDERR DNLIAAVLGD ERLFGLAVLD ITSGNFSVLE IKGWENLLAE LERINPVELL
     IPDDWPPGLP AEKRRGSRRR APWDFERDSA HKSLCQQFAT QDLKGFGCEN LTLAIGAAGC
     LLSYAKETQR TALPHLRSLR HERLDDTVIL DAASRRNLEL DTNLSGGRDN TLQSVMDRCQ
     TAMGTRLLTR WLNRPLRDLT ILQARQTSIT CFLERYRFEN LQPQLKEIGD IERILARIGL
     RNARPRDLAR LRDALSALPE LQQAMSDLDA PHLQQLAQTA GTYPELADLL QRAIIDNPPA
     VIRDGGVLKT GYDAELDDLQ SLSENAGQFL IDLEAREKAR TGLGNLKVGY NRVHGYFIEL
     PSKQAEQAPA DYIRRQTLKG AERFITPELK EFEDKALSAK SRALAREKML YETLLEDLIG
     HLAPLQDTAA ALAELDVLSN LAERALNLDL NCPRFVAEPC MRIEQGRHPV VEQVLSTPFV
     ANDLALDDST RMLVITGPNM GGKSTYMRQT ALIVLLAHIG SFVPAASCEL SLVDRIFTRI
     GSSDDLAGGR STFMVEMSET ANILHNATDK SLVLMDEVGR GTSTFDGLSL AWAAAECLAQ
     LRAYTLFATH YFELTVLPES EPLVTNVHLN ATEHNERIVF LHRVLPGPAS QSYGLAVAQL
     AGVPGKVISR AKEHLQRLET TSLPHEQPRA KPGKPAVPQQ SDMFASLPHP VLDELSKVKV
     DDMTPRQALD LLYTLQTRL