ID   A145_VACCW              Reviewed;          53 AA.
AC   Q80HV6;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   23-FEB-2022, entry version 44.
DE   RecName: Full=Virion membrane protein A14.5;
GN   OrderedLocusNames=VACWR134; ORFNames=A 14.5L;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, INDUCTION, SUBCELLULAR LOCATION, AND ABSENCE OF PHOSPHORYLATION.
RX   PubMed=10756020; DOI=10.1128/jvi.74.9.4085-4092.2000;
RA   Betakova T., Wolffe E.J., Moss B.;
RT   "The vaccinia virus A14.5L gene encodes a hydrophobic 53-amino-acid virion
RT   membrane protein that enhances virulence in mice and is conserved among
RT   vertebrate poxviruses.";
RL   J. Virol. 74:4085-4092(2000).
CC   -!- FUNCTION: Protein probably involved in counteracting host defense,
CC       since it enhances virulence in vivo. {ECO:0000269|PubMed:10756020}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}. Note=Component of the mature virion
CC       (MV) membrane. {ECO:0000269|PubMed:10756020}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       {ECO:0000269|PubMed:10756020}.
CC   -!- PTM: Not phosphorylated.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A14.5 protein family.
CC       {ECO:0000305}.
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DR   EMBL; AY243312; AAO89413.1; -; Genomic_DNA.
DR   RefSeq; YP_233016.1; NC_006998.1.
DR   SMR; Q80HV6; -.
DR   DNASU; 3707532; -.
DR   GeneID; 3707532; -.
DR   KEGG; vg:3707532; -.
DR   Proteomes; UP000000344; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR009372; Poxvirus_A14.5.
DR   Pfam; PF06269; DUF1029; 1.
PE   1: Evidence at protein level;
KW   Late protein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Viral envelope protein; Virion.
FT   CHAIN           1..53
FT                   /note="Virion membrane protein A14.5"
FT                   /id="PRO_0000414116"
FT   TOPO_DOM        1..4
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        26..29
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        51..53
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   53 AA;  6165 MW;  892885E0E0348A8E CRC64;
     MISNYEPLLL LVITCCVLLF NFTISSKTKI DIIFAVQTIV FIWFIFHFVH SAI