ID   MUTS_PSEU5              Reviewed;         859 AA.
AC   A4VJN9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=PST_1505;
OS   Pseudomonas stutzeri (strain A1501).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=379731;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A1501;
RX   PubMed=18495935; DOI=10.1073/pnas.0801093105;
RA   Yan Y., Yang J., Dou Y., Chen M., Ping S., Peng J., Lu W., Zhang W.,
RA   Yao Z., Li H., Liu W., He S., Geng L., Zhang X., Yang F., Yu H., Zhan Y.,
RA   Li D., Lin Z., Wang Y., Elmerich C., Lin M., Jin Q.;
RT   "Nitrogen fixation island and rhizosphere competence traits in the genome
RT   of root-associated Pseudomonas stutzeri A1501.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:7564-7569(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABP79190.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000304; ABP79190.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_014596278.1; NC_009434.1.
DR   AlphaFoldDB; A4VJN9; -.
DR   SMR; A4VJN9; -.
DR   STRING; 379731.PST_1505; -.
DR   EnsemblBacteria; ABP79190; ABP79190; PST_1505.
DR   KEGG; psa:PST_1505; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_6; -.
DR   Proteomes; UP000000233; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..859
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335205"
FT   BINDING         617..624
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   859 AA;  95159 MW;  CF4048684AD36049 CRC64;
     MTKSNADLSA HTPMMQQYWK LKREHPDQLM FYRMGDFYEL FYDDAKKAAA LLDITLTARG
     QSAGTAIPMA GIPFHSAEGY LARLVKLGES VVICEQIGDP ATSKGPVERQ VVRIITPGTV
     SDEALLDERR DNLLAAVVGD EKLFGLSVLD IASGRFSVQE LKGWETLLAE LERLSPAELL
     IPDDWPQGLP LEKRRGVRRR APWDFDRDSA FKSLCQQFST QDLKGFGCEN LTLAIGAAGC
     LLAYAKETQR TALPHLRSLR HERLDDTVIL DGASRRNLEL DVNLAGGREN TLQSVMDRCQ
     TAMGSRLLTR WLNRPLRNRE ILEARQDSIT CLLEHYRFEQ LQPQLKDIGD LERILARIGL
     RNARPRDLAR LRDALAALPQ LQAGMQDLVA PHLLGLAKSI GTYPELADLL ARAIIDNPPA
     VIRDGGVLKT GYDAELDELQ SLSENAGQYL MDLETREKAR TGLANLKVGY NRVHGYFIEL
     PSKQAESAPA DYIRRQTLKG AERFITPELK EFEDKALSAK SRALAREKLL YDELLEMLIG
     HLAPLQESAA ALAELDVLSN LAERALNLDL NRPRFVEQPC LRIEQGRHPV VEQVLETPFV
     ANDLALDDAT RMLVITGPNM GGKSTYMRQT ALIVLLAQIG SFVPAAACEL SLVDRIFTRI
     GSSDDLAGGR STFMVEMSET ANILHNASDR SLVLMDEVGR GTSTFDGLSL AWAAAEQLAR
     LRAFTLFATH YFELTVLPES EPVVANVHLS ATEHNERIVF LHHVLPGPAS QSYGLAVAQL
     AGVPGEVIQR ARDHLSRLET TSLPHEAPRM APGQPAPPMQ SDLFASLPHP VLEELGRINP
     DDVTPRQALE LLYSLKSRI