MUTS_PSYA2
ID MUTS_PSYA2 Reviewed; 1058 AA.
AC Q4FV41;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Psyc_0247;
OS Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Psychrobacter.
OX NCBI_TaxID=259536;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17307 / VKM B-2377 / 273-4;
RX PubMed=20154119; DOI=10.1128/aem.02101-09;
RA Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A., Ivanova N.,
RA Bergholz P.W., Di Bartolo G., Hauser L., Land M., Bakermans C.,
RA Rodrigues D., Klappenbach J., Zarka D., Larimer F., Richardson P.,
RA Murray A., Thomashow M., Tiedje J.M.;
RT "The genome sequence of Psychrobacter arcticus 273-4, a psychroactive
RT Siberian permafrost bacterium, reveals mechanisms for adaptation to low-
RT temperature growth.";
RL Appl. Environ. Microbiol. 76:2304-2312(2010).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000082; AAZ18117.1; -; Genomic_DNA.
DR RefSeq; WP_011279555.1; NC_007204.1.
DR AlphaFoldDB; Q4FV41; -.
DR SMR; Q4FV41; -.
DR STRING; 259536.Psyc_0247; -.
DR EnsemblBacteria; AAZ18117; AAZ18117; Psyc_0247.
DR KEGG; par:Psyc_0247; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_6; -.
DR OMA; TPMMAQY; -.
DR OrthoDB; 15991at2; -.
DR Proteomes; UP000000546; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..1058
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000224396"
FT REGION 130..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 975..999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..999
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 767..774
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 1058 AA; 115409 MW; E87EE8D5C2E5AB2E CRC64;
MSVKPSAQTN DTIQSTSKSV PAASDSLVIG DAIYHLADHT PMMVQYLTMK ANYPQALLLY
RMGDFYELFF DDAKRAAQIL DITLTRRGTD KAGNTIAMAG VPFHAADSYM ARLIAAGQTV
VVCEQIDESA TGNARNTSNT PTMGDKQKKD KSKSAAGTIM RREVVKTLTA GTITDDALIA
PNHTPTVVAI DILIPKSNSK QSLQAAISQM DLAAGTLTTQ TLSANHDDIE GLKTQMLTVL
ARFAPSECII GEALNDSIGG IGEDWLLWLR QSLDCPIIEV AANDFHRQHA SATLCQQFGV
QRLDGLGSGI SDAPLAQSSC AALIHYARQT QQRQVPQINQ LIVEYSDDYL IIDANSQQNL
ELFTPVSSNG TSLLSVLNHC QTPMGRRLLV QQMKRPLRQH SRINLRLDAI ACLLKTDKTS
IESNQASNQA LKHSSLVISL REMLNSIGDI ERISSRIGLM SAKPRDLRKL ADGIASSTQL
TTLLTDSGVS HEQAGLLPML MQQLPAQLPA VQSIAKLIER AIITEPPAHI RDGGMLAAGY
DDEFDRLTHL HDNIQVTLDE MVERARLESQ LPSLKVGFNK VSGFYFELPK MQAKNAPAHF
IRRQTLKSSE RFITDELKDV ETEYLSAQTL ALTREKQLYH ELLTELSSHL AELQQLSAAI
AQIDVLSNWA QLAMTYNWQC PVMSNNDENK DSSNTDNQAS IDISQGRHVV VEAALNPVNA
GNAGNTVNSS NNSSNNSGTT RHNSHFVAND CALGSDANPE RLLLITGPNM GGKSTYMRQT
ALIVLLAHCG SFVPAASAHI GDIDRIFTRI GSADDLAGGK STFMVEMIET ANILNQATNQ
SLVLMDEVGR GTATTDGLAI AHACVNRLLE IGCLTLFATH YFELTKLAQN PKESSGSNDK
LIRNVHVAAS EVDGQLLLLH QIKEGAASSS FGLHVAKMAG IPTQVLNDAK RYLVDNLTID
NLGIDNLSID NLKSNNESAN DDKNDLAKSV KDKRQQTADS DIEKLNLSNI KKTQNMTDIP
QQNQLFSLQD ELHAIDPDSL TPKQAHDLIY HLKKIISR
