ID   MUTS_PSYCK              Reviewed;        1040 AA.
AC   Q1QE46;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Pcryo_0273;
OS   Psychrobacter cryohalolentis (strain ATCC BAA-1226 / DSM 17306 / VKM B-2378
OS   / K5).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Psychrobacter.
OX   NCBI_TaxID=335284;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1226 / DSM 17306 / VKM B-2378 / K5;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D.,
RA   Han C., Tapia R., Sims D.R., Gilna P., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Richardson P.;
RT   "Complete sequence of chromosome of Psychrobacter cryohalolentis K5.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000323; ABE74057.1; -; Genomic_DNA.
DR   RefSeq; WP_011512645.1; NC_007969.1.
DR   AlphaFoldDB; Q1QE46; -.
DR   SMR; Q1QE46; -.
DR   STRING; 335284.Pcryo_0273; -.
DR   PRIDE; Q1QE46; -.
DR   KEGG; pcr:Pcryo_0273; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_1_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002425; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..1040
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335206"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          130..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        130..145
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         759..766
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   1040 AA;  114553 MW;  9BF2AE74F5746180 CRC64;
     MPVKPSAQNN SPSKPTSKSV PVDSDSLVIG DAIYHLADHT PMMVQYLNMK VNYPQALLLY
     RMGDFYELFF EDAKRAAQIL DITLTRRGTD KAGNTIAMAG VPFHAADSYM ARLIAAGQTV
     VVCEQIDESA TGTDNANNPS NAPTMGDKQK KDKSKSTAGT IMRREVVKTL TAGTITDDAL
     IAPNHTPTVV AIDIETPKSN SKQPVQAAVS QMDLAAGTLT TQTISANQDD IESLQTQMLT
     VLARFAPSEC IISEALSDSN GDISEEWLLW LRQHLNCPII EVAANDFHRE HASATLCQQF
     EVQRLDGLGI SGAPLAQSSC AALIHYARQT QQRHVPQLNQ LIVEYNDDYL IIDANSQQNL
     ELFTPVSSNG TSLISVLNHC QTPMGRRLLV QQMKRPLRQH SRINLRLDAI TSLLDTDKQS
     EQCSGNISLV TSLRETLNAI GDIERISSRI GLMSAKPRDL RKLADGIASS AQLTTLLTNA
     GISHEQAGLL PMLMQQLPAQ LPAVQSVAEL IERAIIVEPP AHIRDGGMLA AGYDAEFDRL
     THLHDNIQVT LDEMVERARQ ESQLPSLKVG FNKVSGFYFE LPKMQAKNAP AHFIRRQTLK
     SSERFITNEL KTVETEYLSA QSLALTREKQ LYNELLIRLG SHLAELQQLS AAIAQIDVLN
     NWAQLAITYN WQRPVMSNES KKSSILDNSL ENSHSENGLN NNSQTSINIK EGRHVVVEAV
     LNPIHTHQNN PAKHSSHFVA NDCVLGSYEN PERLLMITGP NMGGKSTYMR QTALIVLLAH
     CGSFVPAARA HIGDIDRIFT RIGSADDLAG GKSTFMVEMI ETANILNQAT NKSLVLMDEV
     GRGTATTDGL AIAHACVNRL VEIGCLTLFA THYFELTKLA QNPKESSGSN DKFIRNVHVA
     ASEIDGQLLL LHQIKDGAAS SSFGLHVAKM AGIPIQVLND AKRYLVDNLS IDNLKPDNES
     IDDDKNELAK SVKDKRQQTY DSNIEKSNIR NLDKKQKNID IPQQNQLFSL QDELQAIDPD
     SLTPKQAHDL LYHLKEIISY