ID   MUTS_PSYIN              Reviewed;         856 AA.
AC   A1T004;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Ping_3383;
OS   Psychromonas ingrahamii (strain 37).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Psychromonadaceae; Psychromonas.
OX   NCBI_TaxID=357804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=37;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Staley J.,
RA   Richardson P.;
RT   "Complete sequence of Psychromonas ingrahamii 37.";
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000510; ABM05069.1; -; Genomic_DNA.
DR   RefSeq; WP_011771621.1; NC_008709.1.
DR   AlphaFoldDB; A1T004; -.
DR   SMR; A1T004; -.
DR   STRING; 357804.Ping_3383; -.
DR   EnsemblBacteria; ABM05069; ABM05069; Ping_3383.
DR   KEGG; pin:Ping_3383; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000639; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..856
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335207"
FT   BINDING         617..624
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   856 AA;  95701 MW;  A629EFDFFBDEEB0B CRC64;
     MTLSAQQLQQ HTPMMQQFLT IKSEVPDTLL FYRMGDFYEL FFDDARKASQ LLGISLTQRG
     KTGGNAIPMA GVPYHSVEGY LAKLIAMGES IAICEQIGDP ATSKGPVERK LVRIITPGTV
     TDEALLNDRQ DNLLCSVYQL QNSFGIASLD LGSGRFIINQ FQHTETLQAE LQRLNPAELL
     YPENFEHMDL IEHLQTIRRR PEWEFELATS KKILNQQFST KDLIGFGVEK AEVALCAAGA
     LLQYIKDTQR TSLPHLQSIQ LEKNIDSVIL DAATRKNLEL TQNLSGGFDN TLAEVLDFTV
     TPMGSRLLKR WIHQPIRNFN TLTYRQTMIQ TLIEQDLSSA LADPLKQIGD VERVIARLAL
     RSARPRDLTR LRTAFSLLPE LQHLIADLPT ELVGKLNKEM GLYPELLTLL EKAVIDNPPV
     IIRDGGVIKE GYNEELDQWR NLAKGATDYL EQLETRERQA TGISTLKVGY NRVHGYYIET
     SRSQSDIVPA HYIRRQTLKN TERYIIAELK EHEDKVLSSR GKALALEKKL YEQLIDLLLP
     HLQNLQSTAQ ALAELDVLNN LAERAVTLNY VRPTLQAENG IEIEEGRHPV VEQVSKTPFI
     ANPVMLNDKR RMLIITGPNM GGKSTYMRQV ALMVLMAHIG SFIPAQQAKI GPVDRIFTRI
     GASDDLASGR STFMVEMTET ANILHNATKN SLVLMDEIGR GTSTFDGLSL AWACAEQLAK
     KIQAYTLFAT HYFELTKLPE NIPELVNVHL DAVEHGDAIA FLHAVQEGAA NKSYGLQVAA
     LAGVPKEVVS NAKNILRQLE LGSQPQANLN EKPLQTTLAF DDAQTNQALL LLANINPDEL
     TPKKALELIY LLKERA