ID   MUTS_RALPJ              Reviewed;         882 AA.
AC   B2U9E4;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Rpic_0993;
OS   Ralstonia pickettii (strain 12J).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=402626;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12J;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T., Detter J.C.,
RA   Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Marsh T., Richardson P.;
RT   "Complete sequence of chromosome 1 of Ralstonia pickettii 12J.";
RL   Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001068; ACD26141.1; -; Genomic_DNA.
DR   RefSeq; WP_012435277.1; NC_010682.1.
DR   AlphaFoldDB; B2U9E4; -.
DR   SMR; B2U9E4; -.
DR   STRING; 402626.Rpic_0993; -.
DR   EnsemblBacteria; ACD26141; ACD26141; Rpic_0993.
DR   KEGG; rpi:Rpic_0993; -.
DR   PATRIC; fig|402626.5.peg.2196; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..882
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093639"
FT   BINDING         629..636
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   882 AA;  96592 MW;  053065865103C5ED CRC64;
     MAEHSAPVLE IDPKYGPFDK HTPMMQQYLR LKSGHPNTLV FYRMGDFYEL FFEDAEKASR
     LLDITLTARG SSNGHPIRMA GIPFHAAEQY LAKLVKLGES VAICEQIGDP ATAKGPVERK
     VVRVVTPGTL TDAALLSDKI NNHLLAIAHL PAKRGAAPLI GLAWLNLVGG ELRVMECSPD
     QLDRELERIR PAEVLADDAT LNTIQVDVAR TRLPDWHFDV EAGTRRLREQ LGVASLVAFG
     AETLTAALAA AGALLNYAAA TQGQSLRHVI GLTVEHESEF IGLDTATRRN LELTETLRGQ
     ESPTLFSLLD TCATSMGSRL LRHWLHHPLR DRAIPQARQQ AIEVLLGGDW QTLRSTLRTL
     SDVERITGRL ALLSARPRDL SSLRDTLARL PEIREELPQS DAAPLLIELY AALTLPEDAH
     ALLQRAVMAE PAAMVRDGGV IARGYDADLD ELRDISENCG QFLVDLEARE RERTGIANLR
     VEYNRVHGFY IEVTNGQAAK VPDDYRRRQT LKNAERYITP ELKAFEDKAL SAQDRALSRE
     KLLYEELLQK LLPHLAEFKR IAAALAQADV LATLAERAHA LSWSRPTLTD APGIELTRAR
     HPVVEQQVEQ FVANDCMLQE ARKLLLITGP NMGGKSTFMR QTALVVLLAY VGAFVPAEAA
     VIGPIDRIFT RIGAADDLAG GRSTFMVEMT EAAAILHRAT PNSLVLMDEI GRGTSTFDGL
     ALAWAIARHL LSHNRSHTLF ATHYFELTQL PQEFAQAANV HLSAVEHGDG IVFLHAVQEG
     PASQSYGLQV AQLAGVPQPV IRAARKRLAW LEQHSADTGA TPQLDLFALA ADMPIVDEGD
     ADAETPDSAL ADALAGIDPD DMTPREALDA LYRLKALASP AA