ID   MUTS_RALSO              Reviewed;         882 AA.
AC   Q8Y093;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=RSc1151;
GN   ORFNames=RS04600;
OS   Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=267608;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GMI1000;
RX   PubMed=11823852; DOI=10.1038/415497a;
RA   Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M.,
RA   Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M.,
RA   Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M.,
RA   Moisan A., Robert C., Saurin W., Schiex T., Siguier P., Thebault P.,
RA   Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A.;
RT   "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL   Nature 415:497-502(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AL646052; CAD14853.1; -; Genomic_DNA.
DR   RefSeq; WP_011001101.1; NC_003295.1.
DR   AlphaFoldDB; Q8Y093; -.
DR   SMR; Q8Y093; -.
DR   STRING; 267608.RSc1151; -.
DR   EnsemblBacteria; CAD14853; CAD14853; RSc1151.
DR   GeneID; 60500664; -.
DR   KEGG; rso:RSc1151; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001436; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..882
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115124"
FT   BINDING         629..636
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   882 AA;  96264 MW;  BBE471873E808A29 CRC64;
     MAEHSAPALE IDPKYGPFDK HTPMMQQYLK LKSAHPHTLV FYRMGDFYEL FFEDAEKAAR
     LLDITLTSRG TTNGQPIRMA GVPFHAVEQY LAKLVKLGES VAICEQIGDP ATTKGPVERK
     VVRVVTPGTL TDAALLSDKV NNHLLAIAQI PGKRGAAPLV GLAWLNLVGG ELRLMECSAE
     QLDRELERIR PAEVLADDAT LNAVAFDVAR TRLPDWHFDV EAGARRLREQ LGVASLVAFG
     CETLTAALAA AGALLNYAAA TQGQSLRHVI GLTVEHESEF IGLDTATRRN LELTETLRGQ
     ESPTLFSLLD TCATSMGSRL LRHWLHHPLR DRAVPQARQQ AIEVLLAGDW QSLRGTLRTL
     SDVERITGRL ALLSARPRDL SSLRDTLARL PEVRDQLPQS DDAQLLGDLH AALAIPEDAH
     ALLQRAVMAE PAAMVRDGGV IARGYDADLD ELRDISENCG QFLVDLEARE RERTGIANLR
     VEYNRVHGFY IEVTNGQAAK VPDDYRRRQT LKNAERYITP ELKAFEDKAL SAQDRALSRE
     KYLYEDLLQK LLPHLPVLKR IAAALAQADV LATLAERAHA LSWSRPALTD APGIELIRAR
     HPVVEQQVEQ FVANDCVLQE TRKLLLITGP NMGGKSTFMR QTALVVLLAY VGAFVPADAA
     TIGPIDRIFT RIGAADDLAG GRSTFMVEMT EAAAILHRAT PNSLVLMDEI GRGTSTFDGL
     ALAWAIARHL LSHNRSHTLF ATHYFELTQL PQEFAQAANV HLSAVEHGDG IVFLHAVQEG
     PASQSYGLQV AQLAGVPQPV IRAARKRLAW LEQHSADTGA TPQLDLFALP SDPSDDDAAE
     AAAPAAPSAL AEALDGIDPD SMTPRDALDA LYRLKALSDA SA