ID   MUTS_RHIEC              Reviewed;         908 AA.
AC   Q2KD76;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=RHE_CH00388;
OS   Rhizobium etli (strain CFN 42 / ATCC 51251).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=347834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFN 42 / ATCC 51251;
RX   PubMed=16505379; DOI=10.1073/pnas.0508502103;
RA   Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.,
RA   Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A.,
RA   Jimenez-Jacinto V., Collado-Vides J., Davila G.;
RT   "The partitioned Rhizobium etli genome: genetic and metabolic redundancy in
RT   seven interacting replicons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000133; ABC89210.1; -; Genomic_DNA.
DR   RefSeq; WP_011423770.1; NC_007761.1.
DR   AlphaFoldDB; Q2KD76; -.
DR   SMR; Q2KD76; -.
DR   STRING; 347834.RHE_CH00388; -.
DR   EnsemblBacteria; ABC89210; ABC89210; RHE_CH00388.
DR   KEGG; ret:RHE_CH00388; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001936; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..908
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335210"
FT   BINDING         662..669
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   908 AA;  98245 MW;  6FFEB9C7D0FDEFF3 CRC64;
     MNARIDIGNE AFSAAELATA ESRASATPMM EQYIEIKANN PGSLLFYRMG DFYELFFEDA
     LEASRALGIT LTKRGQHMGQ DIPMCGVPVH AADDYLQKLI SLGFRVAVCE QIEDPAQAKK
     RGAKSVVKRD VIRLVTPGTI TEEKLLSPSE SNYLMALARI RGGAEPQLAL AWIDISTGVF
     RLAETESSRL LADILRIDPR ELILPDTIFH DAELKPVFDV LGRTAVPQPS VLFDSASAEG
     RIARYFGVST LDGFGSFSRA ELAAAAAAVA YVEKTQIAER PPLGKPERES AASTLFIDPA
     TRANLELART LSGDRNGSLL KAIDRTVTGG GARLLAERLM SPLTDPARIN ARLDSIGFLI
     EEPSLCGKLR DTLKHVPDMP RALSRLALDR GGPRDLWAIR QGLQAAGGLA DLLASAMLPE
     ELDQALSGLQ ALPAGLETLL AETLADELPL LKRDGGFLRD GASAELDEVR ALRDQSRRVI
     AGLQLQYAEE TGIRSLKIKH NNILGYFIEV TAGNAAPMTE TSEAKSRFIH RQTMASAMRF
     TTTELADLES RIANAADRAL TIELEAFDRM TAAVVAQAES IKSGARALAV IDVAAGLALL
     AEEQAYCRPQ VDGSKMFAIE GGRHPVVEQA LRRQAGGPFV ANNCDLSPKT GDKDGAIWLL
     TGPNMGGKST FLRQNALIAI MAQMGSFVPA TSAHIGIVDR LFSRVGASDD LARGRSTFMV
     EMVETAAILN QASDRSLVIL DEIGRGTATF DGLSIAWAAV EHLHEANRCR GLFATHFHEL
     TVLSEKLGRL SNATMRVKEW DGDVIFLHEV GPGAADRSYG IQVARLAGLP ASVVARARDV
     LTRLEDADRK NPASQLIDDL PLFQVAVRRE DAARGPSKVE EALRAMSLDD MTPREAMDAL
     YDLKKKLK