ID   MUTS_RHIL3              Reviewed;         908 AA.
AC   Q1MMA5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=RL0406;
OS   Rhizobium leguminosarum bv. viciae (strain 3841).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=216596;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3841;
RX   PubMed=16640791; DOI=10.1186/gb-2006-7-4-r34;
RA   Young J.P.W., Crossman L.C., Johnston A.W.B., Thomson N.R., Ghazoui Z.F.,
RA   Hull K.H., Wexler M., Curson A.R.J., Todd J.D., Poole P.S., Mauchline T.H.,
RA   East A.K., Quail M.A., Churcher C., Arrowsmith C., Cherevach I.,
RA   Chillingworth T., Clarke K., Cronin A., Davis P., Fraser A., Hance Z.,
RA   Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H.,
RA   Rabbinowitsch E., Sanders M., Simmonds M., Whitehead S., Parkhill J.;
RT   "The genome of Rhizobium leguminosarum has recognizable core and accessory
RT   components.";
RL   Genome Biol. 7:R34.1-R34.20(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AM236080; CAK05897.1; -; Genomic_DNA.
DR   RefSeq; WP_011650199.1; NC_008380.1.
DR   AlphaFoldDB; Q1MMA5; -.
DR   SMR; Q1MMA5; -.
DR   STRING; 216596.RL0406; -.
DR   EnsemblBacteria; CAK05897; CAK05897; RL0406.
DR   KEGG; rle:RL0406; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000006575; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..908
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335211"
FT   BINDING         662..669
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   908 AA;  98323 MW;  038A02371F0E1C88 CRC64;
     MNARIDTGNE AFSAAELATA ESRASATPMM EQYIEIKANN PDSLLFYRMG DFYELFFEDA
     LEASRALGIT LTKRGQHMGQ DIPMCGVPVH AADDYLQKLI SLGFRVAVCE QIEDPAEAKK
     RGAKSVVRRD VVRLVTPGTI TEEKLLSPSE SNYLMALTRI RGSGEALLAL AWIDISTGVF
     RLAETEASRL LADILRIDPR ELILPDTIFH DPELKPVFDV LGRTAVPQPS VLFDSASAEG
     RIARYFGVAT LDGFGTFSRA ELAAAAAAVA YVEKTQIAER PPLGKPERES AASTLFIDPA
     TRANLELART LSGDRNGSLL KAIDRTVTGG GARLLAERLM SPLTDPARIN ARLDSIGFLI
     DEPLLCGNLR DTLKHVPDMP RALSRLALDR GGPRDLSAIR QGLDAAGGVA VMLGKAVLPE
     ELGQALSELQ ALPATLEKLL AETLAEELPL LKRDGGFLRD GANAELDEVR ALRDQSRRVI
     AGLQLQYAEE TGIRSLKIKH NNVLGYFIEV TAGNASPMTE TADAKARFIH RQTMANAMRF
     TTTELADLES RIANAADQAL TIELEAFDRM TAAVVAEAEA IKSGARALAV IDVAAGLALL
     AEEQAYCRPQ VDGSKMFAIE SGRHPVVEQA LRRQAGGPFV ANHCDLSPKT GDRDGAIWLL
     TGPNMGGKST FLRQNALISI LAQMGSFVPA TSAHIGIVDR LFSRVGASDD LARGRSTFMV
     EMVETAAILN QASDRSLVIL DEIGRGTATF DGLSIAWAAV EHLHEANRCR GLFATHFHEL
     TVLSEKLGRL SNATMRVKEW DGDVIFLHEV GPGAADRSYG IQVARLAGLP ASVVARARDV
     LTRLEDADRK NPASQLIDDL PLFQVAVRRE ETARGASKVE EALKAMSLDD MTPREAMDAL
     YDLKKKLK