ID   MUTS_RHILO              Reviewed;         909 AA.
AC   Q98C21;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=mll5328;
OS   Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)
OS   (Mesorhizobium loti (strain MAFF 303099)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Phyllobacteriaceae; Mesorhizobium.
OX   NCBI_TaxID=266835;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 29417 / CECT 9101 / MAFF 303099;
RX   PubMed=11214968; DOI=10.1093/dnares/7.6.331;
RA   Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y.,
RA   Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y.,
RA   Nakayama S., Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M.,
RA   Tabata S.;
RT   "Complete genome structure of the nitrogen-fixing symbiotic bacterium
RT   Mesorhizobium loti.";
RL   DNA Res. 7:331-338(2000).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; BA000012; BAB51800.1; -; Genomic_DNA.
DR   RefSeq; WP_010913139.1; NC_002678.2.
DR   AlphaFoldDB; Q98C21; -.
DR   SMR; Q98C21; -.
DR   STRING; 266835.14025199; -.
DR   EnsemblBacteria; BAB51800; BAB51800; BAB51800.
DR   KEGG; mlo:mll5328; -.
DR   PATRIC; fig|266835.9.peg.4226; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000552; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..909
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115125"
FT   REGION          275..295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         661..668
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   909 AA;  98111 MW;  439440A5F595D5B5 CRC64;
     MNMHSPNEPD APEVMTTPQP GTAAVTPMME QFIEIKAANP DSLLFYRMGD FYELFFDDAE
     KASRALGIVL TKRGKHQGHD IPMCGVPVHA ADDYLQKLIG QGFRVAVCEQ IEDPAEAKKR
     GSKSVVRRDV VRLVTPGTIT EDKLLAPSES SFLMALGRVK GGSDHSFAIA WIDISTGAFR
     VAETTADRLL ADIFRVDPRE LIVAEPVFHD PELRPVFDVL GRVANPQPPS LFDSASATGR
     IARFFDVATP DSFGTFSRAE LSAISGAIAY VEKTQKAERP PLSRPEREEQ GSTLFIDPAT
     RGNLELLRTL SGSREGSLFK AIDRTVTGGG ARLLADRLMA PLTDPAAIGA RLDSVSFFRT
     ETRLCQAVRA SLKSVADMPR ALSRLALNRG GPRDLGALRA GFEAAGAIVE IFAATALPQE
     LAEAMAAIRA LPQALAQHLI QALGEELPLL KRDGGFLRGG YHPELDEMRA LRDESRKVIA
     GLERSLIEET GIRSLKIRHN NVLGYYIEVT ANHHAIMTGS DGAKARFIHR QTMANAMRFT
     TTELAELETK IANAADRALG IELAAFEALT AQAVGEAEKI RAGADALAAI DVSAALALLS
     ESEAWCRPVV DSSLAFEISG GRHPVVEQAL RRSGEGPFVA NDCDLSPEGN AKNGAIWLLT
     GPNMGGKSTF LRQNALIAIL AQTGSFVPAT SAHIGVVDRL FSRVGASDDL ARGRSTFMVE
     MVETAAILNQ AGERALVILD EIGRGTATFD GLSIAWAAVE YLHEKNRCRA IFATHFHEMT
     SLAGKLARLH NVTMRVKEWE GDVVFLHEVG KGAADRSYGV QVARLAGLPE AVVDRAKQVL
     HQLEEGEVSG KTNRLVDDLP LFSVAMKREA PKPVKSDALG AALGDINPDE MTPREALEAL
     YRLKGLAGK