ID   MUTS_RHIME              Reviewed;         916 AA.
AC   P56883;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=DNA mismatch repair protein MutS;
GN   Name=mutS; OrderedLocusNames=R00395; ORFNames=SMc01125;
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11481430; DOI=10.1073/pnas.161294398;
RA   Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA   Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA   Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA   Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA   Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT   "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT   meliloti strain 1021.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 566-916.
RX   PubMed=11274131; DOI=10.1128/jb.183.8.2682-2685.2001;
RA   Rudnick P.A., Arcondeguy T., Kennedy C.K., Kahn D.;
RT   "glnD and mviN are genes of an essential operon in Sinorhizobium
RT   meliloti.";
RL   J. Bacteriol. 183:2682-2685(2001).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; AL591688; CAC41832.1; -; Genomic_DNA.
DR   EMBL; AF227730; AAF37851.1; -; Genomic_DNA.
DR   RefSeq; NP_384501.1; NC_003047.1.
DR   RefSeq; WP_010968548.1; NC_003047.1.
DR   AlphaFoldDB; P56883; -.
DR   SMR; P56883; -.
DR   STRING; 266834.SMc01125; -.
DR   EnsemblBacteria; CAC41832; CAC41832; SMc01125.
DR   GeneID; 61601874; -.
DR   KEGG; sme:SMc01125; -.
DR   PATRIC; fig|266834.11.peg.1768; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001976; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..916
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115126"
FT   BINDING         665..672
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   916 AA;  99182 MW;  EF8651C02364D436 CRC64;
     MNFLMDASNR SGDVLSVSDL ASEESRSTAT PMMEQFIEIK ANNPDSLLFY RMGDFYELFF
     QDAVEASRAL GITLTKRGQH MGQEIPMCGV PVHAADDYLQ KLIASGYRVA VCEQVEDPAE
     AKKRGSKSVV RRDVVRLVTP GTITEDKLLS PSESNYLMAL ARIRSGSEPA YALAWIDIST
     GIFRLAETAE SRLLADILRI EPRELILPDT VFHDPDLRPV FDVLGRVAVP QPAVLFDSAT
     AEGRISRYYG VGTLDGFGSF SRAELAAASA AVSYVEKTQL QERPALGIPE RESAASTLFI
     DPATRANLEL AKTLSGSRDG SLLKSLDRTM TSGGARLLAE RLMSPLTDPE RINQRLDSIE
     VLADQPRFTT DVRDALRRAP DMPRALSRLA LGRGGPRDLG AIQAGMRAAA AISALLSGAE
     LSAELTEARD AIAALPGELL ARLDATLAEE LPLLKRDGGF VREGASAELD EMRALRDQSR
     RVIAGLQLQY CEETGIKSLK IKHNNVLGYF IEVTAGNAGS MTDTDAGRAR FIHRQTMANA
     MRFTTTELAE LETKIANAAD RALAIELETF EAMVREVVAE AEAIKAAALA LATIDVSAGL
     AVLAEEQNYT RPTVDRSRMF AIDGGRHPVV EQALRRQAAN PFVANGCDLS PPNGEQGGAI
     WLLTGPNMGG KSTFLRQNAL IAIMAQTGSF VPAAAAHIGV VDRLFSRVGA SDDLARGRST
     FMVEMVETAA ILNQATDRSL VILDEIGRGT ATFDGLSIAW AAVEHLHEVN RCRGLFATHF
     HELTVLSEKL VRLSNATMRV KEWDGDVIFL HEVGPGAADR SYGIQVARLA GLPASVVARA
     RDVLAKLEDA DRKNPASQLI DDLPLFQVAV RREEAARASS GPSKVEEALK ALNPDDMTPR
     EALDALYALK KELSNR