ID   MUTS_RHIWR              Reviewed;         904 AA.
AC   A5VA00;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Swit_2761;
OS   Rhizorhabdus wittichii (strain DSM 6014 / CCUG 31198 / JCM 15750 / NBRC
OS   105917 / EY 4224 / RW1) (Sphingomonas wittichii).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Rhizorhabdus.
OX   NCBI_TaxID=392499;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 6014 / CCUG 31198 / JCM 15750 / NBRC 105917 / EY 4224 / RW1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C.,
RA   Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Halden R.U., Miller T.R., Salzberg S.L., Eisen J.A.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Sphingomonas wittichii RW1.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000699; ABQ69116.1; -; Genomic_DNA.
DR   AlphaFoldDB; A5VA00; -.
DR   SMR; A5VA00; -.
DR   STRING; 392499.Swit_2761; -.
DR   EnsemblBacteria; ABQ69116; ABQ69116; Swit_2761.
DR   KEGG; swi:Swit_2761; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001989; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..904
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335228"
FT   BINDING         655..662
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   904 AA;  95824 MW;  0160463CA4DD4A2D CRC64;
     MFARLAFGAW PGSPQVAISV RMAQTAKKDM APPASAPTPM MAQYLALKAA AEDCLLFYRM
     GDFFELFFDD AKTASACLDI ALTARGEHDG QPIPMCGVPA HSAEGYLARL IKAGHRVAIA
     DQTESPAEAK KRAGSKALVG RAIVRVVTAG TLTEEALLDS RAANWLVAVA GAGQGADRRI
     GIAAADISTG RFEIAGLIPS ALDAELARLD AAEIVVPEDF EEPPAGAVAW PREHFESVRG
     EERLKRLLGV ATLDGFGAFT RAELAAAGAL IAYLERAGQG SLPFLQPPRR RVVADHMMID
     AATRESLEIT LSQAGVRKGS LLDAVDRTVT GAGARLLGAD LSAPLTDVGA IEARLDLVAL
     FEGDGALRER LRGALRALPD VGRALGRLVA RRGSPRDLGQ LRDGLDQARL LHELLGRAAP
     MPALLAGLLP QLVGHDELVD LLRRALVATP PIDAAQGGYI AEGYDPALDA LRGQGGEGRK
     AIAALEARYR AETGIPSLKI KHNGVLGYHI EVQAKHADPL MTADSGFTHR QTLAGVVRFN
     APDLHEQAMR VGQSGEHALA AEAAHLEELM AAALGRTAEI AATADALARL DVAAALAERA
     AEGGWTRPHF EPHSCFDVIG GRHPVVEAAV AAQGARFVAN DCRLSDQERL WLVTGPNMGG
     KSTFLRQNAA IAILAQAGSP VPATSARLGI VDRLFSRVGA SDNLARGRST FMVEMVETAA
     ILAQATERSF VILDEVGRGT STYDGLAIAW AVVEAVHDIN RCRCLFATHY HELTRLAERL
     DALSLHHVRA REWKGELVLL HELADGPADR SYGIAVAKLA GLSPPVLARA RDVLKKLEAG
     RAATGGLAAG LDDLPLFAAA AQVEEAAPDP LRHEIETIDV DSLSPREALD ILYRLKTLAR
     EAAE