ID   MUTS_RHOBA              Reviewed;         891 AA.
AC   Q7UP05;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=RB7237;
OS   Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1).
OC   Bacteria; Planctomycetes; Planctomycetia; Pirellulales; Pirellulaceae;
OC   Rhodopirellula.
OX   NCBI_TaxID=243090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10527 / NCIMB 13988 / SH1;
RX   PubMed=12835416; DOI=10.1073/pnas.1431443100;
RA   Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W.,
RA   Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R.,
RA   Reinhardt R.;
RT   "Complete genome sequence of the marine planctomycete Pirellula sp. strain
RT   1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; BX294145; CAD75260.1; -; Genomic_DNA.
DR   RefSeq; NP_867713.1; NC_005027.1.
DR   RefSeq; WP_011121304.1; NC_005027.1.
DR   AlphaFoldDB; Q7UP05; -.
DR   SMR; Q7UP05; -.
DR   STRING; 243090.RB7237; -.
DR   PRIDE; Q7UP05; -.
DR   EnsemblBacteria; CAD75260; CAD75260; RB7237.
DR   KEGG; rba:RB7237; -.
DR   PATRIC; fig|243090.15.peg.3505; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_0; -.
DR   InParanoid; Q7UP05; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001025; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..891
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115127"
FT   BINDING         632..639
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   891 AA;  97901 MW;  3BC92071ECB56B69 CRC64;
     MTPMMRQYHE AKEACGDALL FFRMGDFYEL FLDDAKVAAG ILGLTLTSRD KDSENPTAMA
     GFPHHQLDQY LQKLIRAGFR AAVCEQVEDP KAAKGLVRRE ITRVVSAGTL TDEGLLDPKE
     PNYLAAVFAP SQKAREKAQK EAAKTNDPSG GDVVGIAWAE LSSGRFEAGV FPRARLDDEL
     ARIGPAEVLH CEDDASVHPD PTATWSWTAR PAWSYAAADA EKSLCKQLSV ANLEGLGFED
     NGDVAIRAAG AVLCYLKETQ RGSLDHFRSL TCHNRSPVLQ IDAATRRSLE ITRTMRTGSR
     EGALLGVIDR TVTPMGSRML ADHLAAPLID ADAITYRTDA VDEFVRNNNL RSDIRTVLGD
     TYDLTRLLAR VATGRTGPRD LRQIAVTLSG LPALKARLAE RDSACLTRLE SELHLCPELR
     EQLESALNDE CPLSAADGNF IREGFDSELD TLRELARGGK RWIAEYQQRQ MDETGIANLK
     VGYNRVFGYY LEVSNAHKDK IPADFIRKQT LKNCERYITP ELKEYEEKVL AADEKASSRE
     QMLFTLLREN THKHLAILQE VANAIAMTDV VASLAEVAAQ HHWVRPTLTD DSVLRIEGGR
     HPVLDVTMAQ GEFVPNDCIQ SPETGMILLI TGPNMAGKST YIRQVALITL LAQTGSFVPA
     TSAEIGIADR IFARVGASDE LSRGQSTFMV EMVETARILN TATSRSLVIL DEIGRGTSTY
     DGLSLAWAIT EHLHEQIGAR TLFATHYHEL AALQETLPRV ANLSVAVKEW QDEVVFLHRI
     VPGSADKSYG IQVARLAGIP VEVNERAKDV LAQLEADHRD SLDRPTIAPP SGVNGKGSGD
     TYQLTLFGYA DHPLIQEIET VDIDSMSPIQ AWQFLQEAKA KLSAGPKAVK G