ID   MUTS_RHOP2              Reviewed;         911 AA.
AC   Q2J2S1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=RPB_0528;
OS   Rhodopseudomonas palustris (strain HaA2).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=316058;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HaA2;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA   Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Pelletier D.A.,
RA   Kyrpides N., Anderson I., Oda Y., Harwood C.S., Richardson P.;
RT   "Complete sequence of Rhodopseudomonas palustris HaA2.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000250; ABD05239.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2J2S1; -.
DR   SMR; Q2J2S1; -.
DR   STRING; 316058.RPB_0528; -.
DR   EnsemblBacteria; ABD05239; ABD05239; RPB_0528.
DR   KEGG; rpb:RPB_0528; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000008809; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..911
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335216"
FT   BINDING         660..667
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   911 AA;  97816 MW;  868576BF8A5ECA35 CRC64;
     MHRVMTIHPD IAPPPDLPAP AEPPAKVSPM MEQYHEIKAA NPGLLLFYRM GDFYELFFED
     AEIASRALGI TLTKRGKHQG MDIPMCGVPV ERSDDYLHRL IALGHRVAVC EQTEDPAAAR
     ARKSVVRRDV VRLITPGTLT EDTLLDARAN NYLLAIARAR GSSGTDRIGL AWIDISTGEF
     SVTECATGEL SATLARINPN EAIVSDALYS DAELGPSLRE LAAVTPLTRD VFDSATAERR
     LCDYFAVATM DGLAALSRLE AAAAAACVTY VDRTQLGKRP PLSPPSREAT GATMAIDPAT
     RANLELTRTL AGERRGSLLD AIDCTVTAAG SRLLAQRLAA PLTDAAAIAR RLDAVEVFVV
     APALREQIRS ALRAAPDMAR ALARLSLGRG GPRDLASLRD GIVAADQGLQ QLSQLTAPPQ
     EIAAAMAALR RPSRDLCDEL GRALADDLPL QKRDGGFVRD GYEAALDETR KLRDASRLVV
     AAMQARYADD TGVKGLKIRH NNVLGYFVEV TAQHGDRLMA PPLNATFIHR QTLAGQVRFT
     TAELGEIEAK IANAGDRALG LELEIFDRLA ALIETAGEDL RAAAHAFALL DVATALAKLA
     SDDNYVRPEV DQSLSFAIEG GRHPVVEQAL KRAGEPFIAN ACDLSPGPAQ ASGQIWLLTG
     PNMAGKSTFL RQNALIALLA QTGSYVPAAR ARIGIVDRLF SRVGAADDLA RGRSTFMVEM
     VETAAILNQA TERALVILDE IGRGTATFDG LSIAWAAIEH LHEQNRCRAL FATHYHELTA
     LSAKLPRLFN ATVRVKEWRG EVVFLHEVLP GSADRSYGIQ VAKLAGLPAS VVARAKSVLA
     KLEANDRGQP KALIDDLPLF AITARAPAEP SPPSEAEQLI AAVQALHPDE LSPREALDAL
     YALKAKLPKT T